Safety of adjunctive transvaginal beam therapy in the treatment of squamous cell carcinoma of the uterine cervix

Seider, Michael J.; Peters, Lester J.; Jt, Wharton; Oswald, Mary Jane

doi:10.1016/0360-3016(88)90095-8

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…Historically, patients with severe cervical bleeding have been treated with intravaginal cones using superficial and orthovoltage irradiation (5,7) . The irradiation dose administered to our patients was derived from the empiric experience of the author and the dose recommended when transvaginal kilovoltage irradiation has been administered (7,12) . The intravaginal cone technique is cumbersome to use.…”

Section: Discussionmentioning

confidence: 99%

“…Few data in the literature describe the type of irradiation required and dose utilized for hemostatic treatment of invasive cervical carcinoma (1)(2)(3)(4)(5) . Histori-cally, superficial intravaginal cone irradiation has been utilized to control bleeding in patients with cervical cancer (5)(6)(7) . In this communication we describe an HDR method and results of treatment of acute vaginal bleeding from carcinoma of the uterine cervix.…”

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confidence: 99%

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High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma

Grigsby

Portelance

Williamson

2002

Int J Gynecol Cancer

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Grigsby PW, Portelance L, Williamson JF. High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma. Int J Gynecol Cancer 2002;12:18-21. The objective of this study was to evaluate the use of the high dose rate (HDR) cervical ring applicator to control acute cervical bleeding from carcinoma of the uterine cervix. This study consists of 15 patients presenting with invasive carcinoma of the uterine cervix with acute vaginal bleeding requiring transfusion. Initial irradiation, delivered emergently because of vaginal bleeding, consisted of two fractions (5 Gy each fraction to the surface of the cervix) utilizing the HDR intracavitary vaginal ring applicator. Two fractions were administered at one week intervals for a total of 10 Gy to the surface of the cervix. Irradiation doses from the HDR ring applications were not considered into the composite total dose to point A. Diagnostic imaging evaluation and initiation of external irradiation were commenced during this initial weekly interval between fractions. Vaginal bleeding requiring no additional transfusions was achieved in 93% (14/15) of patients. No acute or long-term Grades 3, 4, or 5 bowel or bladder sequelae were noted. In conclusion, HDR cervical ring brachytherapy is effective in controlling acute vaginal bleeding and can be delivered without undue acute or long-term toxicity.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma

Grigsby

Portelance

Williamson

2002

Int J Gynecol Cancer

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Few data in the literature describe the type of irradiation required and dose utilized for hemostatic treatment of invasive cervical carcinoma (1–5) . Historically, superficial intravaginal cone irradiation has been utilized to control bleeding in patients with cervical cancer (5–7) . In this communication we describe an HDR method and results of treatment of acute vaginal bleeding from carcinoma of the uterine cervix.…”

mentioning

confidence: 99%

High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma

Grigsby

Portelance

Williamson

2002

International Journal of Gynecological Cancer

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The objective of this study was to evaluate the use of the high dose rate (HDR) cervical ring applicator to control acute cervical bleeding from carcinoma of the uterine cervix. This study consists of 15 patients presenting with invasive carcinoma of the uterine cervix with acute vaginal bleeding requiring transfusion. Initial irradiation, delivered emergently because of vaginal bleeding, consisted of two fractions (5 Gy each fraction to the surface of the cervix) utilizing the HDR intracavitary vaginal ring applicator. Two fractions were administered at one week intervals for a total of 10 Gy to the surface of the cervix. Irradiation doses from the HDR ring applications were not considered into the composite total dose to point A. Diagnostic imaging evaluation and initiation of external irradiation were commenced during this initial weekly interval between fractions. Vaginal bleeding requiring no additional transfusions was achieved in 93% (14/15) of patients. No acute or long-term Grades 3, 4, or 5 bowel or bladder sequelae were noted. In conclusion, HDR cervical ring brachytherapy is effective in controlling acute vaginal bleeding and can be delivered without undue acute or long-term toxicity.

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Ureteral stricture as a late complication of radiotherapy for stage IB carcinoma of the uterine cervix

McLntyre

Eifel

Levenback

et al. 1995

Cancer

102

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Background. Ureteral stricture is a rare late complication of curative radiotherapy for carcinoma of the cervix. A retrospective study was performed to determine the incidence and latency of radiation‐induced ureteral stricture, to investigate possible contributing factors, and to compare the time course and presenting characteristics of ureteral compromise caused by late radiation injury or tumor recurrence. Methods. The records of 1784 patients with FIGO stage IB carcinoma of the cervix treated with radiotherapy at The University of Texas M. D. Anderson Cancer Center between 1960 and 1989 were reviewed. The characteristics of patients who developed ureteral stricture as a first manifestation of recurrent disease or without evidence of pelvic recurrence were compared. The risk of ureteral compromise was calculated actuarially. Results. There were 29 patients with severe radiation‐induced ureteral stricture. The overall incidences of severe ureteral stenosis were 1.0, 1.2, 2.2, and 2.5% at 5, 10, 15, and 20 years, respectively, reflecting a continuous actuarial risk increase of approximately 0.15% per year. Four patients died of complications from bilateral ureteral stricture. Patients who were treated with centrally blocked external fields or who received more than two transvaginal radiation treatments were at increased risk for developing ureteral stenosis. The risk was similar for patients treated with radiation alone or followed by extrafascial hysterectomy. Conclusions. During the first 5 years after treatment, tumor recurrence is the most common cause of ureteral stricture in patients treated with radiotherapy for carcinoma of the cervix. However, radiation injury to the ureter, although rare, may not become apparent for many years, necessitating continued vigilance throughout the lives of these patients. Cancer 1995; 75:836‐43.

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Safety of adjunctive transvaginal beam therapy in the treatment of squamous cell carcinoma of the uterine cervix

Cited by 7 publications

References 3 publications

High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma

High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma

High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma

Ureteral stricture as a late complication of radiotherapy for stage IB carcinoma of the uterine cervix

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