Safety monitoring of COVID-19 vaccination among adolescents aged 12 to 17 years old in the Republic of Korea

Kim, Seontae; Hwang, Insob; Ko, Mijeong; Kwon, Yunhyung; Lee, Yeon-Kyeng

doi:10.24171/j.phrp.2022.0122

Cited by 9 publications

(14 citation statements)

References 16 publications

(15 reference statements)

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“…1 ; Supplemental Table 2 ). Eventually, 15 observational studies [6] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] met the inclusion criteria ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the 15 included studies were summarized in Table 1 . Briefly, 12 were used for the overall and subgroup analyses [6] , [12] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [23] , [24] , [25] , 2 for the overall analyses [13] , [14] , and 1 for the subgroup analyses only [22] . One study [13] focused on both BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) vaccines, and 14 [6] , [12] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] on BNT162b2 (Pfizer-BioNTech) vaccines alone.…”

Section: Resultsmentioning

confidence: 99%

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Incidence of myopericarditis after mRNA COVID-19 vaccination: A meta-analysis with focus on adolescents aged 12–17 years

Guo

Yang

2023

Vaccine

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Incidence of myopericarditis after mRNA COVID-19 vaccination: A meta-analysis with focus on adolescents aged 12–17 years

Guo

Yang

2023

Vaccine

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“…7 8 This milder clinical course of VAM in an East Asian population compared with other ethnicities is consistent with other studies on Asian populations. 12 14 19 These limited but consistent results imply that VAM in the East Asian adolescent population may have a similar or even milder clinical course than in other populations.…”

Section: Discussionmentioning

confidence: 73%

“…Coronavirus disease 2019 (COVID- 19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in 500 million confirmed cases and 6 million deaths worldwide and was declared as a pandemic on March 11, 2020, by the World Health Organization. 1,2 The vaccine efficacy on COVID-19, including the omicron variant, has been reported to be 70 to 85% in the early phase and more than 50% in the subsequent stage.…”

Section: Introductionmentioning

confidence: 99%

Suspected Myocarditis after mRNA COVID-19 Vaccination among South Korean Adolescents

Kim,

Jun

et al. 2023

J Pediatr Infect Dis

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Objective Since vaccination for coronavirus disease 2019 (COVID-19) has been initiated, rare cases of COVID-19 mRNA vaccination-associated myocarditis (VAM) have been reported worldwide. This study aimed to report the short-term outcomes and the clinical presentation of VAM in South Korean adolescents. Methods In this prospective multicenter study across five tertiary hospitals in South Korea, patients aged 12 to 17 years with symptoms of VAM were included from October 18, 2021, to April 30, 2022. We performed laboratory tests, electrocardiography, chest radiography, echocardiography, and cardiac magnetic resonance imaging studies on these patients. Results A total of 14 patients were diagnosed with VAM during the study period. The median age of the patients was 15.2 years (interquartile range [IQR], 14.6–15.9) and 11 patients (78.6%) were male. All patients had received a messenger RNA Pfizer-BioNTech COVID-19 vaccine. The median latent period from vaccination to symptom onset was 1 (range, 0–8; IQR, 0.8–3.5) day. Chest pain was the most common symptom (11/14, 78.6%), and the median duration of symptoms was 1 week. Except for one patient (7.1%) who was admitted to intensive care unit, most patients (13/14, 93.8%) had a minor and short clinical course without an intensive treatment including an immune modulator. Conclusion VAM in South Korean adolescents had self-limiting clinical courses as reported by previous studies. Despite the small number of cases, our findings, consistent with previous studies, revealed that East Asian adolescents might have a similar or even milder clinical course than adolescents of other ethnicities.

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“…11 KDCA reviewed AEs in adolescents aged 12–17 reported through February 2022. 78 Out of 12,216 AEs, there were 85 suspected cases of anaphylaxis, 74 suspected cases of myocarditis/pericarditis, 2 cases of suspected multisystem inflammatory syndrome, and 2 deaths. The KDCA concluded that the deaths were unrelated to vaccination.…”

Section: Adverse Events Of Covid-19 Vaccines In Koreamentioning

confidence: 99%

COVID-19 Vaccination in Korea: Past, Present, and the Way Forward

et al. 2022

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Since its first emergence in late 2019, severe acute respiratory syndrome coronavirus-2 has claimed more than 6.5 million lives worldwide and continues to infect hundreds of thousands of people daily. To combat this once-in-a-century disaster, several vaccines have been developed at unprecedented speeds. Novel vaccine platforms (messenger ribonucleic acid vaccines and adenoviral vector vaccines) have played a major role in the current pandemic. In Korea, six vaccines, including a domestically developed recombinant vaccine, have been approved. As in other countries, vaccines have been proven to be safe and highly effective in Korea. However, rare serious adverse events and breakthrough infections have undermined public trust in the vaccines, even while the benefits of vaccination far outweigh the risks. The rise of the omicron variant and the subsequent increase in excess mortality demonstrated that while vaccines are a key component of the pandemic response, it alone can fail without non-pharmaceutical interventions like masking and social distancing. The pandemic of coronavirus disease has revealed both the strengths and weaknesses of our healthcare system and pandemic preparedness. When the next pandemic arrives, improved risk communication and vaccine development should be prioritized. To enable timely vaccine development, it is essential to make strategic and sufficient investments in vaccine research and development.

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Safety monitoring of COVID-19 vaccination among adolescents aged 12 to 17 years old in the Republic of Korea

Cited by 9 publications

References 16 publications

Incidence of myopericarditis after mRNA COVID-19 vaccination: A meta-analysis with focus on adolescents aged 12–17 years

Incidence of myopericarditis after mRNA COVID-19 vaccination: A meta-analysis with focus on adolescents aged 12–17 years

Suspected Myocarditis after mRNA COVID-19 Vaccination among South Korean Adolescents

COVID-19 Vaccination in Korea: Past, Present, and the Way Forward

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