Safety, immunogenicity and shedding of LAIV4 in HIV-infected and uninfected children

Curtis, Donna; Ning, Mariangeli Freitas; Armon, Carl; Li, Shaobing; Weinberg, Adriana

doi:10.1016/j.vaccine.2015.07.082

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…In a study comparing immunogenicity and shedding of LAIV4 among 46 HIV-infected (CD4+ counts >200 cells/µL) and 56 uninfected persons aged 2 through 25 years, adverse events were similar between the two groups. Shedding of vaccine virus was somewhat more prevalent among the HIV-infected participants, 67% of whom shed any vaccine virus up to 14-21 days postvaccination, compared with 50% of uninfected participants (p = 0.14) (413).…”

Section: Persons At Higher Risk For Influenza-related Complicationsmentioning

confidence: 85%

Prevention and Control of Seasonal Influenza with Vaccines

Grohskopf

Sokolow²,

Broder³

et al. 2016

MMWR Recomm. Rep.

381

279

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Section: Persons At Higher Risk For Influenza-related Complicationsmentioning

confidence: 85%

Prevention and Control of Seasonal Influenza with Vaccines

Grohskopf

Sokolow²,

Broder³

et al. 2016

MMWR Recomm. Rep.

381

279

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“…We chose day 21 to measure vaccine response, in line with previous work. [8][9][10] Nasopharyngeal swabs, oral fluid, and serum samples were stored at -70°C before further processing.…”

Section: Methodsmentioning

confidence: 99%

Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study

Lindsey

Jagne

Armitage

et al. 2019

The Lancet Respiratory Medicine

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Background The efficacy and effectiveness of the pandemic H1N1 (pH1N1) component in live attenuated influenza vaccine (LAIV) is poor. The reasons for this paucity are unclear but could be due to impaired replicative fitness of pH1N1 A/California/07/2009-like (Cal09) strains. We assessed whether an updated pH1N1 strain in the Russianbackbone trivalent LAIV resulted in greater shedding and immunogenicity compared with LAIV with Cal09. Methods We did an open-label, prospective, observational, phase 4 study in Sukuta, a periurban area in The Gambia. We enrolled children aged 24-59 months who were clinically well. Children received one dose of the WHO prequalified Russian-backbone trivalent LAIV containing either A/17/California/2009/38 (Cal09) or A/17/New York/15/5364 (NY15) based on their year of enrolment. Primary outcomes were the percentage of children with LAIV strain shedding at day 2 and day 7, haemagglutinin inhibition seroconversion, and an increase in influenza haemagglutinin-specific IgA and T-cell responses at day 21 after LAIV. This study is nested within a randomised controlled trial investigating LAIV-microbiome interactions (NCT02972957).

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“…Many national health authorities recommend immunisation of HIV+ individuals against influenza due to potential for increased susceptibility and/or disease severity 19 . Conventional or adjuvanted influenza vaccines are immunogenic in HIV+ adults 20 21 22 23 and children 24 25 26 27 , however the induction and maintenance of influenza-specific antibody titres is frequently lower than in comparable HIV− controls, particularly in the absence of ART or in infected subjects with low CD4 T cell counts 24 26 28 29 30 31 . Similarly, the establishment of influenza vaccine-elicited memory B cell responses, as measured by polyclonal stimulation and B cell ELISpot, are diminished compared to healthy controls 12 .…”

mentioning

confidence: 99%

HIV-dependent depletion of influenza-specific memory B cells impacts B cell responsiveness to seasonal influenza immunisation

Wheatley

Kristensen

Lay

et al. 2016

Sci Rep

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Infection with HIV drives significant alterations in B cell phenotype and function that can markedly influence antibody responses to immunisation. Anti-retroviral therapy (ART) can partially reverse many aspects of B cell dysregulation, however complete normalisation of vaccine responsiveness is not always observed. Here we examine the effects of underlying HIV infection upon humoral immunity to seasonal influenza vaccines. Serological and memory B cell responses were assessed in 26 HIV+ subjects receiving ART and 30 healthy controls immunised with the 2015 Southern Hemisphere trivalent inactivated influenza vaccine (IIV3). Frequencies and phenotypes of influenza hemagglutinin (HA)-specific B cells were assessed by flow cytometry using recombinant HA probes. Serum antibody was measured using hemagglutination inhibition assays. Serological responses to IIV3 were comparable between HIV+ and HIV− subjects. Likewise, the activation and expansion of memory B cell populations specific for vaccine-component influenza strains was observed in both cohorts, however peak frequencies were diminished in HIV+ subjects compared to uninfected controls. Lower circulating frequencies of memory B cells recognising vaccine-component and historical influenza strains were observed in HIV+ subjects at baseline, that were generally restored to levels comparable with HIV− controls post-vaccination. HIV infection is therefore associated with depletion of selected HA-specific memory B cell pools.

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Safety, immunogenicity and shedding of LAIV4 in HIV-infected and uninfected children

Cited by 13 publications

References 31 publications

Prevention and Control of Seasonal Influenza with Vaccines

Prevention and Control of Seasonal Influenza with Vaccines

Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study

HIV-dependent depletion of influenza-specific memory B cells impacts B cell responsiveness to seasonal influenza immunisation

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