Safety, feasibility and weight loss after transoral gastroplasty: First human multicenter study

Transoral surgery for morbid obesity

“…Transoral techniques are rapidly becoming a reality in the armamentarium of weight loss procedures and it is our responsibility to ensure that these techniques are safe and effective in the long-term. Patients/trials n = 82 in 2 trials n = 32 in 2 trials n = 20 in 1 trial n = 3 in 2 trials n = 39 in 1 trial n = 64 [28] n = 21 [31] n = 12 [33] n = 18 [29] n = 11 [30] n = 25 [34] Short term morbidity Nausea, vomiting, abdominal pain Nausea, vomiting, epigastric pain, transient dysphagia Not reported Nausea, vomiting, abdominal pain Sore throat, epigastric pain…”

“…Incomplete distal sleeves (n = 3/21 [31] ) Mortality None None None None None Average length of procedure 45 min [28] 160 min [31] 195 min 41 min [33] 35 min 125 min [29] 84 min [30] 39 min [34] Tested in randomized trials No No No Yes [34] Yes %EWL Not reported 1 mo 21.1 [28] 16.2 [31] ; 19.2 [30] 16.0 [33] ; 15.0 [34] 10.6 3 mo 39.6 [28] 22.6 [31] ; 33.…”

“…Devière et al [30] conducted the first human prospective, single-arm trial examining the safety and feasibility of the TOGA system in 21 patients. Primary outcomes focused on safety and appearance of the pouch at 6 mo.…”

“…The Transoral Gastroplasty System (TOGA; Satiety Inc., Palo Alto, CA) was the first endoscopic device to use staplers to create full thickness plications along the lesser curve of the stomach, effectively creating a sleeve [30] . The technique entails upper endoscopy and placement of a guide wire over which a 60 Fr bougie is introduced to dilate and test for any resistance prior to device introduction.…”

Invazív módszerek az elhízás kezelésében

“…Az első közlés Devière és munkatársaitól 21 esetről számol be (EWL: 16,2%, 22,6% és 24,4 az 1., 3. és 6. hónap után). Egy héten belül alig volt szövődmény, de a 6 hónapos endoszkópos kontrollnál 13 esetben találtak varratelégte-lenséget [25]. A legutóbbi beszámoló 2011-ben jelent meg, 67 esetben alkalmazták a módszert.…”