Recent evidence has shown that the diverging diamond interchange (DDI) design improves the safety of the ramp terminals and the overall safety of the interchange. What is still not known is the safety effect that a DDI has on adjacent intersections and the speed-change lanes (SCLs) at freeway entrances and exits. This study addressed this void by examining DDI installations in Missouri. The early and many DDI implementations in Missouri provided a rich data set with which to conduct this study. Twelve major signalized intersections adjacent to the DDI ramp terminals were examined. Thirty-two SCL facilities, 16 freeway entrances, and 16 exits from 11 DDI sites also were examined. A manual review was done to assign 4,073 crash reports to corresponding facilities. The empirical Bayes (EB) method was used to estimate the safety effect of the DDI on adjacent facilities. No evidence showed that the DDI design had any effect, positive or negative, on the crashes that occurred at the entrance or exit SCLs. After DDI implementation, the changes were not statistically significant for SCL crash frequency, property damage only (PDO) crashes, and total crashes. For signalized intersections next to the DDI ramp terminals, the EB analysis showed a 6.5% decrease in fatalities and injuries, which was not statistically significant. The analysis also showed a 19.5% increase in PDO and a 12% increase in total crashes, albeit statistically significant only at the 90% confidence level. In summary, no strong evidence was found that DDIs affected safety, either negatively or positively, on adjacent SCLs or intersections.