Safety Evaluation of Robenidine in the Feed of Broiler Chickens

Efficacy Studies With Robenidine, A New Type of Anticoccidial, in the Diet

“…Robenz® robenidine, l,3-bis(p-chlorobenzylideneamino)guanidine hydrochloride, first reported by Kantor et al (1970) to have high broad spectrum activity and Berger et al (1972) who proved that its margin of safety is at least sixfold, is a novel anticoccidial for use in chickens. Additional data confirming the high efficacy of robenidine in battery and floor pen studies have appeared in the literature (Badiola et al, 1970;Kantor, 1973 a,b;Reid era/., 1970;Ryley and Wilson, 1971;Waletzky et al, 1970).…”

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum

“…Robenidine ( Figure 1 a), formerly called robenzidene, is a veterinary drug developed in the early 1970s to treat coccidiosis caused by parasites in the Eimeria genus. 4 − 10 Robenidine is frequently added to animal feed to prevent and treat coccidiosis in chickens, 11 other fowl, 12 and rabbits. 13 Eimeria and Plasmodium , the parasite responsible for malaria infections, are both members of the Apicomplexan phylum, distinguished by the presence of the apical complex and frequent presence of the apicoplast organelle.…”

“…Robenidine (Figure a), formerly called robenzidene, is a veterinary drug developed in the early 1970s to treat coccidiosis caused by parasites in the Eimeria genus. − Robenidine is frequently added to animal feed to prevent and treat coccidiosis in chickens, other fowl, and rabbits …”