Safety Evaluation of Essential Oils

Kuttan, Ramadasan; Liju, Vijayasteltar Belsamma

doi:10.1002/9781119149392.ch12

Cited by 11 publications

(22 citation statements)

References 96 publications

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“…activity. In a preliminary study, T. NF-κB also plays an important role in cell division and apoptosis and regulates the expression of genes involved in apoptosis (Kuttan, Kumar, Guruvayoorappan, & Kuttan, 2007). Active NF-κB is most commonly composed of two subunits; specifically, p50 and p65.…”

Section: Lung Cancermentioning

confidence: 99%

Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties

Hatamipour

Ramezani

Tabassi

et al. 2018

Journal Cellular Physiology

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The eradication of cancer in a patient remains an elusive challenge despite advances in early detection and diagnosis, chemo- and immunotherapy, pinpoint radiation treatments, and expert surgical intervention. Although significant gains have been made in our understanding of cancer cell biology, a definite cure for most cancers does not exist at present. Thus, it is not surprising that the research and medical communities continue to explore the importance and therapeutic potential of natural products in their multimodality cancer treatment approach. Curcuminoids found in turmeric are one such class of natural products that have been extensively investigated for their potential to halt the progression of cancer cell proliferation and, more important, to stop metastasis from occurring. In this review, we examine one curcuminoid (demethoxycurcumin [DMC]) largely because of its increased stability and better aqueous solubility at physiological pH, unlike the more well-known curcuminoid (curcumin), which is largely unabsorbed after oral ingestion. The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC's action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer. Additionally, this review will attempt to provide an overview of DMC's mechanism of action by modulating apoptosis, cell cycle, angiogenesis, metastasis, and chemosensitivity. Lastly, it is hoped that increased understanding will be gained concerning DMC's interactive role with microRNA-551a, 5' adenosine monophosphate-activated protein kinase, nuclear factor-κB, Wnt inhibitory factor-1, and heat shock protein 70 to affect the progression of cancer.

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Section: Lung Cancermentioning

confidence: 99%

Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties

Hatamipour

Ramezani

Tabassi

et al. 2018

Journal Cellular Physiology

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“…Although EO s of O. vulgare and T. vulgaris have acquired Generally Recognized as Safe (status from the Flavour and Extract Manufacturers Association and got approved by the US Food and Drug Administration (FDA) for safety food use [ 79 , 80 ]), there is limited published research on the safety of EO vapors per se [ 51 ]. As EOs are complex blends of components, individual volatile compounds need to be assessed as potential allergens.…”

Section: Discussionmentioning

confidence: 99%

Validation of Qualitative Broth Volatilization Checkerboard Method for Testing of Essential Oils: Dual-Column GC–FID/MS Analysis and In Vitro Combinatory Antimicrobial Effect of Origanum vulgare and Thymus vulgaris against Staphylococcus aureus in Liquid and Vapor Phases

Netopilova

Houdková

Urbanová

et al. 2021

Plants

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Combinatory action of antimicrobial agents such as essential oils (EOs) show to be an effective strategy to overcome the problem with increasing antibiotic resistance of microorganisms, including Staphylococcus aureus. The objective of this study was to evaluate in vitro antimicrobial interactions between Origanum vulgare and Thymus vulgaris EOs against various S.aureus strains in both liquid and vapor phases using the broth volatilization checkerboard method. Fractional inhibitory concentrations (FICs) were determined for both liquid and vapor phases, and the composition of EOs was analyzed by gas chromatography-mass spectrometry using dual-column/dual-detector gas chromatograph. Results of oregano and thyme EOs combination showed additive effects against all S. aureus strains in both phases. In several cases, sums of FICs were lower than 0.6, which can be considered a strong additive interaction. The lowest FICs obtained were 0.53 in the liquid phase and 0.59 in the gaseous phase. Chemical analysis showed that both EOs were composed of many compounds, including carvacrol, thymol, γ-terpinene, and p-cymene. This is the first report on oregano and thyme EOs interactions against S. aureus in the vapor phase. It also confirms the accuracy of the broth volatilization checkerboard method for the evaluation of combinatory antimicrobial effects of EOs in the vapor phase.

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“…Studies suggest that curcumin may have antitumor, antioxidant, and anti-inflammatory properties (Altaf et al, 2012). According to Kuttan et al (2007) curcumin induced cell cycle arrest by reducing the expression of cyclin D1, cdk1, cdc-25, allowing cells to survive, thus providing a way for the apoptotic machinery to act. Yarru (2008) stated that broilers do not generally live long enough to develop cancer, being raised from 6 to 7 weeks.…”

Section: Pathways In Cancermentioning

confidence: 99%

Effects of aflatoxin Bâ‚ (AFBâ‚) on hepatic gene expression in pigs and turkeys

Murarolli¹

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My special thanks to my wife and best friend Marina S. Murarolli who gave me all the support and love during happy and hard times, always been by my side, helping me to make decisions. I also would like to thank my parents, Airton and Neide, for all the love and always supporting all my decisions. My brother, Vinicius, and my sister, Flaveli, for the love and friendship. My parents-in-law, Vera and Tomas, and my sister-inlaw, Marcela, always helping and advising us with their experience.Thanks to all my Brazilian friends, who makes me feel at home

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Safety Evaluation of Essential Oils

Cited by 11 publications

References 96 publications

Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties

Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties

Validation of Qualitative Broth Volatilization Checkerboard Method for Testing of Essential Oils: Dual-Column GC–FID/MS Analysis and In Vitro Combinatory Antimicrobial Effect of Origanum vulgare and Thymus vulgaris against Staphylococcus aureus in Liquid and Vapor Phases

Effects of aflatoxin Bâ‚ (AFBâ‚) on hepatic gene expression in pigs and turkeys

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Safety Evaluation of Essential Oils

Cited by 11 publications

References 96 publications

Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties

Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties

Validation of Qualitative Broth Volatilization Checkerboard Method for Testing of Essential Oils: Dual-Column GC–FID/MS Analysis and In Vitro Combinatory Antimicrobial Effect of Origanum vulgare and Thymus vulgaris against Staphylococcus aureus in Liquid and Vapor Phases

Effects of aflatoxin Bâ‚ (AFBâ‚) on hepatic gene expression in pigs and turkeys

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Effects of aflatoxin Bâ‚ (AFBâ‚) on hepatic gene expression in pigs and turkeys