Safety evaluation of E12, W8, X17, and Y9 potatoes: Nutritional evaluation and 90-day subchronic feeding study in rats

Mukerji, Pushkor; Rudgers, Gary W.; Gibson, Christopher; Roper, Jason M.

doi:10.1016/j.yrtph.2020.104712

Cited by 3 publications

(8 citation statements)

References 45 publications

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“…The absence of adverse effects in our study are consistent with those described in other studies in which processed GM crops with enhanced agronomic traits have shown the absence of clinical effects or histopathological abnormalities in the organs or tissues of animals 22‐37 . Other safety assessment studies of GMPs showed the absence of negative effects on rats 19,38,39 . In contrast, in some cases, side effects have been detected in GMP‐fed rats.…”

Section: Discussionsupporting

confidence: 92%

“…[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] Other safety assessment studies of GMPs showed the absence of negative effects on rats. 19,38,39 In contrast, in some cases, side effects have been detected in GMP-fed rats. Ewen and Pusztai 40 reported that rats fed with GMPs containing Galanthus nivalis lectin exhibited proliferative and antiproliferative effects in the rats' gut.…”

Section: Discussionmentioning

confidence: 99%

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Subacute toxicity studies of meals prepared from genetically modified potato overexpressing the StDREB1 or the VvWRKY2 transcription factor in rats

et al. 2022

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BACKGROUND Potato tubers from genetically modified plants overexpressing the StDREB1 or the VvWRKY2 transcription factors that exhibited improved tolerance to salt and resistance to Fusarium solani infection were characterized and evaluated for safety in a 30 day rat feeding study. Male Wistar rats were split into four groups and provided with a diet composed of 33% (w/w) of either one of the two genetically modified potatoes (GMPs), 33% of the commercial Spunta variety (Sp), or a control group fed with the basal rats' diet. The influence of the GMPs on rat behavior and overall health parameters was evaluated and compared with that of commercial potato (i.e. the Sp group) and control diet. RESULTS Small differences were noticed in the chemical composition of the different tubers, but all the diets were adjusted to an identical caloric level. Results showed no sign of toxic or detrimental effects on the rats' overall health as a result of these diets. The rats fed with the GMPs meal showed hematological and biochemical compositions of the plasma comparable to the control groups. No histopathological damage nor any structural disorganization, severe congestion, or acute inflammation were noticed in the rats' tissues. CONCLUSION Under these study conditions, the GMP diets did not induce any apparent or significant adverse effects on rats after 30 days of dietary administration in comparison with rats fed diets with the corresponding non‐transgenic diet and the standard diet group. These two GMPs were therefore considered to be as safe as their commercial comparator. © 2022 Society of Chemical Industry.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Subacute toxicity studies of meals prepared from genetically modified potato overexpressing the StDREB1 or the VvWRKY2 transcription factor in rats

et al. 2022

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“…Another cassette reduces the expression of the α-glucan, water dikinase gene (also called the starch-associated R1 gene) and the phosphorylase L gene ( PhL ). This combination of genes significantly reduced acrylamide levels in fried potatoes. ,,, The reduction of the number of black spots is achieved by silencing of the polyphenol oxidase 5 gene ( Ppo5 ). There are 16 approved GM potatoes with genes inserted to reduce asparagine production, levels of reducing sugars, and formation of black spots.…”

Section: Modified Product Qualitymentioning

confidence: 99%

“…A total of 4 out of 16 approved GM potatoes also have integrated genes for foliar resistance to LB marked as the second generation of Simplot Innate . Some of them have been successfully tested for their safety …”

Section: Modified Product Qualitymentioning

confidence: 99%

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Approved Genetically Modified Potatoes (Solanum tuberosum) for Improved Stress Resistance and Food Safety

Křížkovská

Viktorová

Lipov

2022

J. Agric. Food Chem.

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Potatoes (Solanum tuberosum) are one of the most important crops worldwide. However, its production and nutrient content are endangered by both biotic and abiotic stresses. The main yield losses are caused by pest damage (e.g., Colorado potato beetle and aphids), virus disease (e.g., Potato leafroll virus and Potato viruses Y and X), or oomycete pathogens (like Phytophthora infestans), which also significantly affect the production of antinutrients and toxic metabolites of plants. Therefore, the use of genetic engineering could be an efficient tool, not harmful to the environment, and beneficial to the consumer. In this review, we focus on the main sources of problems in the field of potato production according to approved genetic modifications, their traditional solution and positive impact of gene transfection reducing economic losses, use of insecticides, and improving the nutritional properties of potatoes. We summarize all transgenic events that have been performed on potatoes and have been approved for cultivation and/or direct use or processing as feed or food.

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Characterization of host-effector transcription dynamics during pathogen infection in engineered late blight resistant potato

2023

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Safety evaluation of E12, W8, X17, and Y9 potatoes: Nutritional evaluation and 90-day subchronic feeding study in rats

Cited by 3 publications

References 45 publications

Subacute toxicity studies of meals prepared from genetically modified potato overexpressing the StDREB1 or the VvWRKY2 transcription factor in rats

Subacute toxicity studies of meals prepared from genetically modified potato overexpressing the StDREB1 or the VvWRKY2 transcription factor in rats

Approved Genetically Modified Potatoes (Solanum tuberosum) for Improved Stress Resistance and Food Safety

Characterization of host-effector transcription dynamics during pathogen infection in engineered late blight resistant potato

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