Safety, efficacy, and stability indices of LASEK correction in moderate myopia and astigmatism

Taneri, Suphi; Feit, R; Azar, Dimitri T.

doi:10.1016/j.jcrs.2004.02.070

Cited by 53 publications

(22 citation statements)

References 43 publications

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“…Ever since the 1990s, LASEK has been used clinically as a safe, effective, and predictable method to treat myopia and myopic astigmatism (Taneri et al, 2004). The visual acuity after LASEK is similar to that following other procedures such as excimer laser corneal refractive surgery.…”

Section: Discussionmentioning

confidence: 99%

Characterization of abnormal epithelium after laser-assisted subepithelial keratectomy using in vivo confocal microscopy

Zuo¹,

Cw²,

Zhou³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study compared the abnormal corneal epithelium after laser-assisted subepithelial keratectomy (LASEK) with dystrophic cornea using in vivo using confocal microscopy (IVCM) and examined the effects of the abnormal epithelium on postoperative recovery of uncorrected distance visual acuity (UDVA) and sub-basal nerve plexus regeneration. The UDVA and wound healing were examined in 50 eyes of 25 patients undergoing LASEK at 1 week, 1 month, and 1 year postoperatively, including the visual acuity, slit lamp microscopy, and IVCM. After 1 week, the corneal epithelium was healed in all patients, but abnormal epithelial cells were detected in 33/50 patients using IVCM. Abnormal cells were limited to the surgical margin, and highly reflective granules were observed underneath. At 1 month and 1 year postoperatively, the abnormal epithelium was unchanged in size. At 1 year postoperatively, there were clear differences between the sub-basal nerve plexus in the normal and abnormal epithelium. At 1 J. Zuo et al. 4750©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4749-4756 (2015) month postoperatively, the UDVA was >1.0 in 88% of patients, which increased to 94% at 1 year, and there was no clear difference in the UDVA between abnormal (N = 33) and normal (N = 17) epithelium. After LASEK, abnormal epithelial cells may arise at the margin of the epithelial flap and persist 1 year postoperatively accompanied by poor regeneration of the sub-basal nerve plexus. However, this does not affect the UDVA postoperatively. The abnormal epithelium may be caused by residual necrotic basal cell debris on the epithelial basement membrane and abnormal neurotrophic metabolism between the corneal epithelium and nerve plexus.

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Section: Discussionmentioning

confidence: 99%

Characterization of abnormal epithelium after laser-assisted subepithelial keratectomy using in vivo confocal microscopy

Zuo¹,

Cw²,

Zhou³

et al. 2015

Genet. Mol. Res.

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“…It has no flap-related complications, reduces the risk of keratectasia associated with LASIK and had been shown to be a safe, effective and predictable treatment for low [1], mild [2] and high [3]- [6] myopia from its introduction [7] [8]. Nevertheless, a clinically significant haze has occurred in >30% [7] [9] of eyes at 3 months, 6.9% [4] of at 6 months and 3.8% [10] of eyes at 1 year.…”

Section: Introductionmentioning

confidence: 99%

Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

Kumano¹,

Soejima²,

Numa³

et al. 2014

OJOph

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Purpose: Additional analyses of outcomes of laser-assisted subepithelial keratectomy (LASEK) are still necessary to improve the safety of LASEK. Therefore, in our study, outcomes were assessed retrospectively in 561 eyes that underwent LASEK treatment. Methods: Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA) and residual spherical equivalent were analyzed at 3 and 6 months postoperatively. We assessed four subgroups based on the degree of preoperative myopia considering mean BSCVA and loss of two or more lines. Results: Mean UCVAs and BSCVAs were obtained at 3 and 6 months postoperatively (1.23/1.35 and 1.23/1.37, respectively). The mean predictability was within ±0.125 diopters. Conversely, the safety indexes were 0.94 and 0.96 respectively, and the efficacy indexes were 0.86 and 0.86 at 3 and 6 months postoperatively, respectively. 8.4% eyes and 5.2% eyes lost two or more lines of BSCVA at 3 and 6 months postoperatively, respectively. The mean BSCVAs of the high or ultra-high groups were significantly lower than those of the low or mild groups both 3 months and 6 months postoperatively. The incidence rates of losing two or more lines of BSCVA in the high or ultra-high myopia groups were significantly greater than in the low or mild groups at 3 months and 6 months postoperatively. Conclusion: LASEK predictably corrected myopia achieving >1.2 in UCVA and BSCVA. However, the safety and efficacy indexes were <1.0, which were related to the loss of two or more lines of BSCVA. Since the incidence rates of losing two or more lines of BSCVA were greater in the high or ultra-high myopia groups, we consider LASEK as more safely performed in patients with low to mild preoperative myopia.

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“…[1][2][3][4][5][6] Despite the disadvantages of LASEK over LASIK (eg, slower visual recovery and higher postoperative discomfort), surface ablation has become the technique of choice in patients with thin corneal pachymetry, those at risk for trauma, and those with corneal surface problems such as dry eye, recurrent erosion syndrome, or epithelial basement membrane disease. 7,8 Even though excimer laser corneal refractive surgery (LASIK and surface ablation) has become highly precise, the predictability of the technique remains an issue, especially in eyes with high degrees of ametropia (either myopia 9,10 or hyperopia 11,12 ).…”

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confidence: 99%

Influence of preoperative keratometry on refractive results after laser-assisted subepithelial keratectomy to correct myopia

Benito-Llopis¹,

Teus²,

Sánchez-Pina³

et al. 2008

Journal of Cataract and Refractive Surgery

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Safety, efficacy, and stability indices of LASEK correction in moderate myopia and astigmatism

Abstract: The long-term safety and effectiveness of LASEK for the correction of low to moderate myopia and astigmatism were demonstrated. The treatment effect stabilized after 4 weeks.

Cited by 53 publications

References 43 publications

Characterization of abnormal epithelium after laser-assisted subepithelial keratectomy using in vivo confocal microscopy

Characterization of abnormal epithelium after laser-assisted subepithelial keratectomy using in vivo confocal microscopy

Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

Influence of preoperative keratometry on refractive results after laser-assisted subepithelial keratectomy to correct myopia

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