Safety Data of Injectable Nonanimal Stabilized Hyaluronic Acid Gel for Soft Tissue Augmentation

Friedman, Paul M.; Mafong, Erick A.; Kauvar, Arielle N. B.; Geronemus, Roy G.

doi:10.1097/00042728-200206000-00010

Cited by 135 publications

(202 citation statements)

References 11 publications

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“…The conduit's chemical composition of hyaluronic acid polymer chains should be ideal for engraftment purposes, inasmuch as HA is a biodegradable and biocompatible extracellular matrix component with low host immune response [39,70,71]. HA oligomers, and thus HA-degradation products, can have pro-or anti-inflammatory effects depending on their molecular weight [72][73][74].…”

Section: Discussionmentioning

confidence: 99%

Schwann-cell cylinders grown inside hyaluronic-acid tubular scaffolds with gradient porosity

et al. 2016

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Cell transplantation therapies in the nervous system are frequently hampered by glial scarring and cell drain from the damaged site, among others. To improve this situation, new biomaterials may be of help. Here, novel single-channel tubular conduits based on hyaluronic acid (HA) with and without poly-L-lactide acid fibers in their lumen were fabricated. Rat Schwann cells were seeded within the conduits and cultured for 10 days.The conduits possessed a three-layered porous structure that impeded the leakage of the cells seeded in their interior and made them impervious to cell invasion from the exterior, while allowing free transport of nutrients and other molecules needed for cell survival. The channel's surface acted as a template for the formation of a cylindrical sheath-like tapestry of Schwann cells continuously spanning the whole length of the lumen. Schwann-cell tubes having a diameter of around 0.5 mm and variable lengths can thus be generated. This structure is not found in nature and represents a truly engineered tissue, the outcome of the specific cell-material interactions. The conduits might be useful to sustain and protect cells for transplantation, and the biohybrids here described, together with neuronal precursors, might be of help in building bridges across significant distances in the central and peripheral nervous system.

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Section: Discussionmentioning

confidence: 99%

Schwann-cell cylinders grown inside hyaluronic-acid tubular scaffolds with gradient porosity

et al. 2016

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“…Les effets secondaires retardés à type de nodules et de granulomes à corps étranger sont également rares et ils peuvent survenir plusieurs années après leur injection [13,18,19]. Certains AH très réticulés comme le Restylane® ou ayant des particules de grandes taille comme le Sub-Q® ont une résorp-tion lente (12 à 18 mois), ce qui favoriserait les réactions d'encapsulation chronique [5,13,[20][21][22].…”

Section: Discussionunclassified

Complication après injection d’acide hyaluronique : présentation d’un cas

d’Elbée¹,

Fricain²

2013

Med Buccale Chir Buccale

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Résumé -Les produits de comblement à base d'acide hyaluronique (AH) constituent une référence dans la correction et l'augmentation de volume des tissus mous faciaux. Ils ont une longue durée d'action, sont peu immunogènes et peuvent être éliminés par injection locale de hyaluronidase. Ces avantages expliquent leur utilisation fréquente. Des complications aiguës ou chroniques, mineures ou sévères, peuvent survenir après leur injection, même réalisée par un praticien expérimenté. Le cas d'une patiente ayant souffert de complications infectieuses et inflammatoires chroniques après injection d'acide hyaluronique est rapporté. Abstract -Complication following the injection of hyaluronic acid: a case report. Hyaluronic acid (HA) fillershave become the material of choice for soft-tissue augmentation of the face. They are longer lasting, less immunogenic and can be broken down by hyaluronidase. These advantages make HA fillers the most common of the temporary fillers on the market. However, early and delayed complications, ranging from minor to severe, can occur following HA-filler injection even if administered by an experienced practictioner. The case of a patient who suffered from chronic infectious and inflammatory complications following the injection of hyaluronic acid is reported.

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“…Adverse reactions to HA consisting primarily of localized hypersensitivity reactions and injection site inflammation are uncommon and occur in 0.05-0.15% of cases (Friedman et al [26]). The most common early or immediate, non-allergic, local, and transient side effects are injection site reactions such as pain, mild to moderate edema, ecchymoses and hematoma; palpability, hypercorrection, and bluish discoloration may also occur secondary to superficial injection of the implant and inappropriate technique [19,27].…”

Section: Discussionmentioning

confidence: 99%