2015
DOI: 10.1016/j.jhep.2015.06.019
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Safety, complications and outcome of large volume paracentesis with or without albumin therapy in children with severe ascites due to liver disease

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Cited by 30 publications
(31 citation statements)
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References 26 publications
(26 reference statements)
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“…These complications are mitigated by low-volume paracenteses and albumin replacement. Although a recent study by Sarma et al of 32 children in India with severe ascites noted no occurrence of acute kidney injury after largevolume paracentesis, data from the adult literature document rates of kidney injury after largevolume paracentesis to be as high as 20% (20). The ways in which paracentesis might precipitate renal injury in this setting are unknown, but postulated to be due to a renal vasoconstriction from cytokine stimulation of the sympathetic nervous system and activation of the renin-angiotensin-aldosterone pathway (21).…”
Section: Discussionmentioning
confidence: 93%
“…These complications are mitigated by low-volume paracenteses and albumin replacement. Although a recent study by Sarma et al of 32 children in India with severe ascites noted no occurrence of acute kidney injury after largevolume paracentesis, data from the adult literature document rates of kidney injury after largevolume paracentesis to be as high as 20% (20). The ways in which paracentesis might precipitate renal injury in this setting are unknown, but postulated to be due to a renal vasoconstriction from cytokine stimulation of the sympathetic nervous system and activation of the renin-angiotensin-aldosterone pathway (21).…”
Section: Discussionmentioning
confidence: 93%
“…In the other patients, who maintain a level of urinary excretion of sodium greater than 30 mEq/day, the diuretic treatment may be maintained in order to delay the reaccumulation of the ascites and thereby also the need for periodic evacuation paracentesis to be performed so often [6,7].…”
Section: Periodic Evacuation Paracentesismentioning
confidence: 99%
“…45,84 A recent observational study in children with these characteristics showed similar results. 59 There is consensus that albumin infusion plays a significant role in HRS management. 5,6,8,9,76 For this reason, it is also recommended in these situations.…”
Section: Therapeutic Options Albumin Prescriptionmentioning
confidence: 99%