Safety Assessment of Potential Probiotic Lactobacillus fermentum MTCC-5898 in Murine Model after Repetitive Dose for 28 Days (Sub-Acute Exposure)

Samtiya, Mrinal; Bhat, Mohd Iqbal; Gupta, Taruna; Kapila, Rajeev

doi:10.1007/s12602-019-09529-6

Cited by 13 publications

(2 citation statements)

References 36 publications

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“…As earlier in our laboratory, probiotic Lactobacillus fermentum (LF:MTCC-5898), isolated from infant feces, had shown promising immunomodulatory attributes and anti-oxidative capacity in aged mice [12]. In addition, variable doses of L. fermentum were also found safe and nontoxic to weaning mice after four weeks of orogastric challenge [13]. Furthermore, in vitro studies have shown the ability of the L. fermentum (LF: MTCC-5898) to ameliorate the E. coli induced barrier dysfunction and maintain immune homeostasis [14,15].…”

Section: Introductionmentioning

confidence: 66%

Lactobacillus fermentum (MTCC-5898) based fermented whey renders prophylactic action against colitis by strengthening the gut barrier function and maintaining immune homeostasis

Kaur

Gupta

Kapila

et al. 2022

Microbial Pathogenesis

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Section: Introductionmentioning

confidence: 66%

Lactobacillus fermentum (MTCC-5898) based fermented whey renders prophylactic action against colitis by strengthening the gut barrier function and maintaining immune homeostasis

Kaur

Gupta

Kapila

et al. 2022

Microbial Pathogenesis

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“…The mice were observed every day. One day after the last administration, the mice were subjected to blood routine examination and dissected for visceral examination in terms of routine means (Samtiya et al 2019). Briefly, the concentration of red blood cells (RBC), white blood cells (WBC), hemoglobin (HGB), lymphocytes (LYM), granulocytes (GRA) and platelets (PLT) were detected by an automatic animal blood cell analyzer in the blood routine examination.…”

Section: Evaluation Of the Safety Of Mk-sq-1 On Micementioning

confidence: 99%

Evaluation of safety and probiotic properties of a strain of Enterococcus faecium isolated from chicken bile

Shi

Zhai

et al. 2019

J Food Sci Technol

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Probiotics are important bacteria due to their benefit on human health. In this study, four strains of lactic acid bacteria from chicken bile were isolated and the strain with the best antimicrobial activity was selected for further identification and evaluation on its probiotic traits and safety. The strain was identified as Enterococcus faecium by biochemical characterization and 16S rDNA gene sequencing. The strain, named E. faecium MK-SQ-1, was tolerant to acid (pH 3.0), bile salts (up to 0.3%) or trypsin (up to 0.4%) for 3 h and it was able to survive from high temperature (up to 60 °C) for 15 min. This strain inhibited the growth of Salmonella enteritidis and Staphylococcus aureus intermediately. The genes responsible for virulence including asa1, cylA, efaA, esp, gelE and hyl were absent and the mice administrated orally with a very high dose (2 9 10 9 CFU) of the strain daily for 35 days were not found abnormal. The strain enhanced the serum IgG level and phagocytic index of mice significantly by daily oral administration at a high dose (2 9 10 8 CFU) for 21 days (p \ 0.05). The strain did not have multi-antibiotic resistance and vancomycin resistance. Comprehensive evaluation showed E. faecium MK-SQ-1 could be a candidate as a probiotic strain used in human or animals.

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A20 Restores Impaired Intestinal Permeability and Inhibits Th2 Response in Mice with Colitis

Chen

et al. 2019

Dig Dis Sci

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Safety Assessment of Potential Probiotic Lactobacillus fermentum MTCC-5898 in Murine Model after Repetitive Dose for 28 Days (Sub-Acute Exposure)

Cited by 13 publications

References 36 publications

Lactobacillus fermentum (MTCC-5898) based fermented whey renders prophylactic action against colitis by strengthening the gut barrier function and maintaining immune homeostasis

Lactobacillus fermentum (MTCC-5898) based fermented whey renders prophylactic action against colitis by strengthening the gut barrier function and maintaining immune homeostasis

Evaluation of safety and probiotic properties of a strain of Enterococcus faecium isolated from chicken bile

A20 Restores Impaired Intestinal Permeability and Inhibits Th2 Response in Mice with Colitis

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