Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics

Scott, Laura N.; Fiume, Monice M.; Bergfeld, Wilma F.; Belsito, D.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, D.C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Heldreth, Bart

doi:10.1177/10915818221124809

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…Niacinamide is known for its anti-inflammatory and barrier-stabilizing effects [30] and hydrolyzed wheat protein has conditioning effects on the skin and hair based on ionic interactions [31]. The further contained panthenol also bears hair-and skin-conditioning functions [32]. Tocopherol is well-known for its antioxidative effects in skin [33], while glycerin is used as a humectant [34].…”

Section: Discussionmentioning

confidence: 99%

Follicular Delivery of Caffeine from a Shampoo for Hair Retention

et al. 2023

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A key factor in the prevention of hair loss is the provision of optimal conditions on the scalp. In this regard, reduction of oxidative stress on the scalp is one critical requirement to support the hair follicles to function optimally. Recently, a novel shampoo formulation technology containing anti-oxidants such as piroctone olamine has been demonstrated to improve hair retention based on micellar degradation and coacervation effects. Caffeine has also been shown to exhibit anti-oxidant activity including the ability to inhibit lipid peroxidation. As with piroctone olamine, it is expected that follicular delivery of caffeine will enhance its anti-oxidant activity in a region that will be beneficial for hair retention. In this study, two shampoo formulations as well as a control formulation were applied to the calf area of n = 9 male participants. The technique of differential tape stripping was applied to obtain the caffeine penetrated to the stratum corneum and to the hair follicles. Isotope-dilution liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was performed to demonstrate caffeine follicular delivery from the shampoo formulas. The results showed that the percentage of caffeine recovered in the hair follicles was 8–9% of the caffeine absorbed into the skin and matched an existing caffeine-based shampoo. In conclusion, a novel shampoo formulation technology has been developed that effectively delivers beneficial anti-oxidants to improve hair retention. This new shampoo is expected to be especially useful in the goal of retaining hair during aging.

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