Safety Assessment of Microneedle Technology for Transdermal Drug Delivery: A Review

Zhu, Dan; Zhang, Xiao Peng; Zhang, Bao Li; Hao, Yu; Guo, Xin Dong

doi:10.1002/adtp.202000033

Cited by 24 publications

(11 citation statements)

References 146 publications

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“…This is usually done by storing MNs and their cargo at various temperatures, including −25 • C, 4 • C, 20 • C, 40 • C and 60 • C, followed by analytical assessments. Generally, the protein cargo of MNs has better storage stability and longer shelf-life due to the rigid glassy microneedle matrices restraining the molecular mobility and limiting access to atmospheric oxygen [74]. This can be further extended by the incorporation of stabilisers, including trehalose and sucrose.…”

Section: Biocompatibility Biodegradability and Stabilitymentioning

confidence: 99%

Microneedles in Drug Delivery: Progress and Challenges

Avcil¹,

Çelik²

2021

Micromachines

107

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In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals for several applications, including vaccines, drugs, and biomolecules for skin-related problems. The advantages of microneedle patch technology have been extensively evaluated in the latest literature; hence, the academic publications in this area are rising exponentially. Like all new technologies, the microneedle patch application has great potential but is not without limitations. In this review, we will discuss the possible limitations by highlighting the areas where a great deal of improvements are required. Emphasising these concerns early on should help scientists and technologists to address the matters in a timely fashion and to use their resources wisely.

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Section: Biocompatibility Biodegradability and Stabilitymentioning

confidence: 99%

Microneedles in Drug Delivery: Progress and Challenges

Avcil¹,

Çelik²

2021

Micromachines

107

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show abstract

“…The immunogenicity of the skin makes it a highly sensitive organ for MN vaccine delivery, but MNs could also cause side effects such as mild and temporary erythema to the skin during the insertion process [ 126 ]. This is one of the safety issues that should be considered with all types of MN vaccines.…”

Section: Challenges and Prospects Of Mns Delivery Of Vaccinesmentioning

confidence: 99%

Microneedles: An Emerging Vaccine Delivery Tool and a Prospective Solution to the Challenges of SARS-CoV-2 Mass Vaccination

Feng

Wong

et al. 2023

Pharmaceutics

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Vaccination is an effective measure to prevent infectious diseases. Protective immunity is induced when the immune system is exposed to a vaccine formulation with appropriate immunogenicity. However, traditional injection vaccination is always accompanied by fear and severe pain. As an emerging vaccine delivery tool, microneedles overcome the problems associated with routine needle vaccination, which can effectively deliver vaccines rich in antigen-presenting cells (APCs) to the epidermis and dermis painlessly, inducing a strong immune response. In addition, microneedles have the advantages of avoiding cold chain storage and have the flexibility of self-operation, which can solve the logistics and delivery obstacles of vaccines, covering the vaccination of the special population more easily and conveniently. Examples include people in rural areas with restricted vaccine storage facilities and medical professionals, elderly and disabled people with limited mobility, infants and young children afraid of pain. Currently, in the late stage of fighting against COVID-19, the main task is to increase the coverage of vaccines, especially for special populations. To address this challenge, microneedle-based vaccines have great potential to increase global vaccination rates and save many lives. This review describes the current progress of microneedles as a vaccine delivery system and its prospects in achieving mass vaccination against SARS-CoV-2.

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“…Despite the fact that MNs do penetrate the skin, they are labeled “safe” due to their small size. Microneedles’ safety can be assessed by the resultant pain, degree of skin irritation, stability during storage, and in vivo degradation ( 58 ).…”

Section: Microneedles’ Safetymentioning

confidence: 99%

Microneedle-Based Vaccine Delivery: Review of an Emerging Technology

et al. 2022

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Vaccination has produced a great improvement to the global health by decreasing/eradicating many infectious diseases responsible for significant morbidity and mortality. Thanks to vaccines, many infections affecting childhood have been greatly decreased or even eradicated (smallpox, measles, and polio). That is why great efforts are made to achieve mass vaccination against COVID-19. However, developed vaccines face many challenges with regard to their safety and stability. Moreover, needle phobia could prevent a significant proportion of the population from receiving vaccines. In this context, microneedles (MNs) could potentially present a solution to address these challenges. MNs represent single dose administration systems that do not need reconstitution or cold-chain storage. Being self-administered, pain-free, and capable of producing superior immunogenicity makes them a more attractive alternative. This review explores microneedles’ types, safety, and efficacy in vaccine delivery. Preclinical and clinical studies for microneedle-based vaccines are discussed and patent examples are included. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1208/s12249-022-02250-8.

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Safety Assessment of Microneedle Technology for Transdermal Drug Delivery: A Review

Cited by 24 publications

References 146 publications

Microneedles in Drug Delivery: Progress and Challenges

Microneedles in Drug Delivery: Progress and Challenges

Microneedles: An Emerging Vaccine Delivery Tool and a Prospective Solution to the Challenges of SARS-CoV-2 Mass Vaccination

Microneedle-Based Vaccine Delivery: Review of an Emerging Technology

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