Safety Assessment of Mesenchymal Stem Cells in Musculoskeletal Implantation

Asatrian, Greg; Pan, Angel; Scott, Michelle; James, Aaron W.

doi:10.2174/9781608059942115010003

Cited by 1 publication

(2 citation statements)

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“…Demineralized bone matrix grafts, synthetic and natural polymers, bioactive ceramics, cross-linked hydrophilic hydrogels, metals, and composite scaffolds are often used as cell-laden scaffolds to retain cells and control the release of bioactive factors (Figure 2) [75]. PSCs have been the subject of investigation in the context of scaffolds in various preclinical models to explore their osteogenic potential using DBM [74,[81][82][83], collagen sponge [66], hydrogel [84,85], bone matrix [68][69][70], or polymer coated hydroxyapatite [6].…”

Section: Recent Preclinical and Clinical Application Of Pericytesmentioning

confidence: 99%

“…Concerning modern clinical practice, bone-healing therapies are based on the local delivery of cells to the fracture site in combination with growth factors and scaffolds (Table 4). PSCs have been the subject of investigation in the context of scaffolds in various preclinical models to explore their osteogenic potential using DBM [74,[81][82][83], collagen sponge [66], hydrogel [84,85], bone matrix [68][69][70], or polymer coated hydroxyapatite [6].…”

Section: Recent Preclinical and Clinical Application Of Pericytesmentioning

confidence: 99%

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The Therapeutic Potential of Pericytes in Bone Tissue Regeneration

Issabekova,

Kudaibergen,

Sekenova

et al. 2023

Biomedicines

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Pericytes, as perivascular cells, are present in all vascularized organs and tissues, and they actively interact with endothelial cells in capillaries and microvessels. Their involvement includes functions like blood pressure regulation, tissue regeneration, and scarring. Studies have confirmed that pericytes play a crucial role in bone tissue regeneration through direct osteodifferentiation processes, paracrine actions, and vascularization. Recent preclinical and clinical experiments have shown that combining perivascular cells with osteogenic factors and tissue-engineered scaffolds can be therapeutically effective in restoring bone defects. This approach holds promise for addressing bone-related medical conditions. In this review, we have emphasized the characteristics of pericytes and their involvement in angiogenesis and osteogenesis. Furthermore, we have explored recent advancements in the use of pericytes in preclinical and clinical investigations, indicating their potential as a therapeutic resource in clinical applications.

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