Safety assessment of Streptococcus thermophilus IDCC 2201 used for product manufacturing in Korea

Abstract

Lactic acid bacteria have been considered safe and commonly used in foods and fermentation processes (Bernardeau et al., 2006; Zielinska & Kolonzyn-Krajewska, 2018). Typically, they are Grampositive, mostly nonmotile, nonspore-forming, facultative anaerobic (or microaerophilic), and rod-(or cocci-) shaped bacteria that are utilized in fermented dairy and nondairy products such as fermented vegetables, meats, and beverages (Nuraida, 2015). Although the majority of probiotics contain Lactobacillus and Bifidobacterium, Streptococcus genus is one of the most widely used probiotic strain. Streptococcus thermophilus has been generally isolated from traditional fermented milk and yogurt products (Vendramin et al., 2017; Zhang et al., 2019). In particular, S. thermophilus has been used as a starter for dairy products because of rapid acidifying capacity during fermentation process (Naumenko et al., 2019; Santos et al., 2019). It has been also reported to exhibit several health-beneficial effects such as growth inhibition of many pathogenic bacteria and strong adherence to the gastrointestinal tract (Braun et al., 2020; Iyer et al., 2010; Wu et al., 2014). Although probiotics have been regarded as GRAS (generally recognized as safe) strains, recent significant developments in the field

Enhanced ceramides production by Lactobacillus rhamnosus IDCC 3201 and its proposed mechanism

“…L. rhamnosus IDCC 3201 from breast-fed infant's feces [15] and Streptococcus thermophilus IDCC 2201 from home-made yogurt [16] were industrial strains, while the other bacterial strains were isolated from kimchi (Korean fermented food). All the strains were incubated in an in-house medium designed by Ildong Bioscience, centrifuged, and freeze-dried to obtain cell density at > 10 10 colony forming units (CFU)/g.…”

Safety evaluation of Lactococcus lactis IDCC 2301 isolated from homemade cheese

“…L. lactis IDCC 2301 was assessed to determine whether it was susceptible to the nine antibiotics that are commonly used for the treatment of enterococcal infections (EFSA & FEEDAP, 2012; Ban et al., 2020). The nine antibiotics were ampicillin, clindamycin, chloramphenicol, erythromycin, gentamicin, kanamycin, streptomycin, tetracycline, and vancomycin.…”

“…Protein‐rich fermented foods contain a high amount of biogenic amines (Jeong & Lee, 2015). For food safety purposes, tyramine and histamine are considered the most important amino acids and are responsible for various poisoning in fish and food‐induced migraines (Ban et al., 2020). In our study, biogenic amines, including tyramine, histamine, putrescine, 2‐phenethylamine, and cadaverine, were not detected in L. lactis IDCC 2301.…”

Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed <i>Streptococcus thermophilus</i> MN-ZLW-002

“…Streptococcus thermophilus (S. thermophilus) has been widely used in fermented dairy products for its excellent fermentation characteristics and therefore has a long consumption history [13,14]. Emerging evidence has shown that fermented foods could increase food nutrition and have more health benefits for reducing the risk of metabolic syndrome, colorectal cancer, and obesity [15].…”

“…Furthermore, in the neonatal rat model, the probiotic mixture Golden Bifido (including active Lactobacillus bulgaricus, Bifidobacterium, and S. thermophilus) upregulated the expression of mucin in the intestinal mucosa and reduced intestinal permeability, thereby improving neonatal bacteremia and meningitis caused by Escherichia coli K1 [17]. Therefore, S. thermophilus might be a promising probiotic strain [14,18]. Our previous research results showed that inactivated MN002 has the ability to inhibit the differentiation of preadipocytes in vitro, and in animal experiments, inactivated Streptococcus thermophilus MN-ZLW-002 was observed to reduce the weight gain of mice induced by a high-fat diet on early stage [19].However, the health benefits of live S. thermophilus on HFD-induced metabolic disorders remain unclear.…”