Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics

Burnett, Christina L.; Boyer, Ivan; Bergfeld, Wilma F.; Belsito, D.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, D.C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Gill, Lillian J.; Heldreth, Bart

doi:10.1177/1091581819836089

Cited by 8 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 In 2019, the Panel advised industry to continue minimizing the concentrations of the sensitizing impurities, highlighting that DMAPA in oleamidopropyl dimethylamine seems to exceed the limit recommended. 9 Despite this, we found that the majority of the DMAPA-positive patients (39/68; 57.3%), all with clinical relevance, reported the onset of the dermatitis during the last 2 years thus demonstrating that DMAPA is still present at sensitizing concentrations in many products as an impurity.…”

Section: Discussionmentioning

confidence: 65%

“…In conclusion, we believe that legislative interventions on DMAPA to improve consumer safety are advisable. As stated by Burnett et al, DMAPA should be present in cosmetic products at a concentration lower than 0.01%. We would also stress that DMAPA should be tested in the baseline series.…”

Section: Discussionmentioning

confidence: 92%

“…In December 2010, the Cosmetic Ingredient Review Expert Panel reviewed the safety of fatty acid amidopropyl dimethylamines, concluding that they were safe when formulated in nonsensitizing levels, based on quantitative risk assessment, and considered DMAPA at a concentration of 0.01% in raw cocamidopropyl betaine in finished cosmetic products to not be sensitizing . In 2019, the Panel advised industry to continue minimizing the concentrations of the sensitizing impurities, highlighting that DMAPA in oleamidopropyl dimethylamine seems to exceed the limit recommended …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Contact allergy to 3‐dimethylaminopropylamine in 5140 consecutive Italian patients: A one‐year retrospective multicenter SIDAPA study

et al. 2019

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Contact allergy to 3‐dimethylaminopropylamine in 5140 consecutive Italian patients: A one‐year retrospective multicenter SIDAPA study

et al. 2019

View full text Add to dashboard Cite

“…Pomegranate seed oil, which is a rich source of vitamin F, is used in the production of cosmetics with a renewing, nourishing, moisturizing, and refreshing effect on the skin [99,100]. The concentrations of EFAs in cosmetics vary [101]. For example, linoleic acid is used at up to 3.4% in face, neck, hand, and body skin care products and at up to 21.8% in rinse-off skin cleansing products.…”

Section: Vitamin Fmentioning

confidence: 99%

Health Effects of Dyes, Minerals, and Vitamins Used in Cosmetics

Wargala

Sławska

Zalewska

et al. 2021

Women

View full text Add to dashboard Cite

The average woman uses 12 different cosmetic products every day, but they can have a negative effect on human health. Therefore, in recent years, consumer preferences have changed towards buying natural or ecological cosmetics free from preservatives or unnecessary dyes. The aim of this work is to discuss the use of dyes, minerals, and vitamins in cosmetics in terms of their safety and impact on human health. These substances are very important in the cosmetics industry. Most of them are of natural origin. Some minerals used in the production of face masks or creams are recommended to work against inflammations such as ulcers and acne. Clay minerals have exceptional qualities, among others, low or no toxicity and high bio-compatibility. However, some of them may be harmful. For example, the safety of using talc has been widely debated in recent years. Cosmetic-grade talc cannot contain detectable fibrous asbestos minerals. Moreover, talc should not be applied to the skin when the epidermal barrier is missing or significantly disrupted. The use of talc in cosmetic products in the European Union is restricted. Vitamins are one of the most commonly used, biologically active, and easily accessible components in cosmetics. For example, provitamin B5 (D-panthenol) is a bioactive substance. In cosmetic preparations, it has a softening, repairing, and anti-inflammatory effect and is responsible for regulating sebum secretion. However, some vitamins may be harmful to human health. For example, the use of skin-whitening cosmetics containing vitamin C causes allergic contact dermatitis, whereas the most common adverse effect of topical use of vitamin A is skin irritation, erythema, and peeling. Dyes, which are used to color cosmetics, do not improve the condition of the skin, hair, or nails. Some of them may be harmful to human health. For example, the dye CI 60730 (Acid Violet 43) is prohibited for use in eye products and cosmetics that have contact with mucous membranes. In conclusion, some of the popular cosmetic ingredients discussed in this paper may exert a negative influence on human health, and many of these harmful effects have been discovered recently. Therefore, there is a need for further studies on the possible negative effects of dyes, minerals, and vitamins used in cosmetic products.

show abstract

“…FDA dissuades pregnant/nursing women and small children from using personal care products containing chlorphenesin (anti-fungal and anti-bacterial preservative) [16] . The sensitizing reactions with Amidopropyl Dimethylamines (anti-static agent) was due to the impurities like 3,3-dimethylaminopropylamine [17] . Two of the 16 main ingredients used in OTC sunblock products are safe, the FDA said.…”

Section: Introductionmentioning

confidence: 99%

Cosmetics’ Safety: Gray Areas with Darker Inside

Mohiuddin

Road²

2019

Journal of Dermatological Research

View full text Add to dashboard Cite

Cosmetics and personal care products are ubiquitous. Currently, an increasing number of compounds are being assimilated in the and to various types of chemicals, got from a few sources, may cause the alleged "cocktail effect" because of the synergistic interaction of various substances and, likewise, the "added substance effect" in light of the nearness of a similar ingredient in numerous items. Actually, every one of the ingredients utilized in cosmetic items meet certain regulatory prerequisites. Notwithstanding, the utilization of numerous substances is permitted inside specific limits, because of their toxicity at higher concentrations.

show abstract

Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics

Cited by 8 publications

References 39 publications

Contact allergy to 3‐dimethylaminopropylamine in 5140 consecutive Italian patients: A one‐year retrospective multicenter SIDAPA study

Contact allergy to 3‐dimethylaminopropylamine in 5140 consecutive Italian patients: A one‐year retrospective multicenter SIDAPA study

Health Effects of Dyes, Minerals, and Vitamins Used in Cosmetics

Cosmetics’ Safety: Gray Areas with Darker Inside

Contact Info

Product

Resources

About