Safety assessment of aqueous extract from leaf Smallanthus sonchifolius and its main active lactone, enhydrin

Barcellona, Carolina Serra; Cabrera, Wilfredo M.; Honoré, Stella M.; Mercado, María Inés; Sánchez, Sara S.; Genta, Susana B.

doi:10.1016/j.jep.2012.09.021

Cited by 26 publications

(18 citation statements)

References 23 publications

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“…Subchronic toxicity studies are important tools in evaluating the safety profile of herbal medicines or chemical compounds isolated from plants, given that acute toxicity studies are not sufficient to describe a safety profile effectively. In the present work, we adopted a 90‐day toxicity study to assess the safety profile of the 10% decoction of S. macroscyphus and polymatin A, which is a well‐accepted method for evaluating toxicity in long‐term drug administration (Lahlou et al , ; Serra‐Barcellona et al , ).…”

Section: Discussionmentioning

confidence: 99%

Polymatin A fromSmallanthus macroscyphusleaves: A safe and promising antidiabetic compound

et al. 2016

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Smallanthus macroscyphus is an herb native to South America whose leaves are a source of antidiabetic compounds, although complete information about their safe use is not available yet. This study was developed to evaluate the toxicity profile of both 10% decoction and the sesquiterpene lactone polymatin A from S. macroscyphus leaves through in vitro cytotoxicity assays and in vivo subchronic oral toxicity. Cell viability of Hep-G2, COS1, CHO-K1 and Vero cell lines decreased in a concentration-dependent manner when cells were incubated with 0.4-200 μg ml(-1) of dry extract or 0.12-60 μg ml(-1) of polymatin A. In subchronic studies, decoction was orally administered to Wistar rats for 90 days at daily doses of 70, 140 and 280 mg kg(-1) of dry extract, whereas polymatin A was administered in the same way at doses of 7, 14 and 28 mg kg(-1) . No toxicity signs or deaths were observed. There were no changes in the behavior, body or organ weights, hematological, biochemical or urine parameters of the rats. No histopathological lesions were observed in the examined organs. The results indicate that the 10% decoction and polymatin A from S. macroscyphus leaves may be considered as non-toxic substances at a wide range of doses, including the effective hypoglycemic dose. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Polymatin A fromSmallanthus macroscyphusleaves: A safe and promising antidiabetic compound

et al. 2016

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“…Some of above-mentioned terpenes (sonchifolin, uvedalin, enhydrin, and related compounds fluctuanin, 8β-tigloyloxymelampolid-14-oic acid methyl ester and 8β-methacryloyloxymelampolid-4-oic acid methyl ester) are also reported to be antibacterial compounds [77,79,80]. The main lactone of yacon leaves is enhydrin that has antidiabetic properties, so much so that it was included in a patented anti-diabetic pharmaceutical formulation [90]. Melampolide-type sesquiterpene lactones shown to inhibit NO production in LPS-stimulated murine macrophage RAW 264.7 cells [91].…”

Section: Phytochemical Profile Of Smallanthus Sonchifolius Leavesmentioning

confidence: 99%

“…They also inhibit glucose transport through gastrointestinal cells by inhibiting the functioning of the sodium glucose co-transporter (S-GLUT-1) [86]. The yacon leaves contain enhydrin, which increases the number of β-cells and the level of insulin mRNA in the pancreatic islets of rats with streptozotocin-induced diabetes [90]. Enhydrin also inhibits α-glucosidase activity, a similar inhibitory effect possesses smallanthaditerpenic acids A, B, C, and D isolated, which are also contained in the leaves of yacon [89,90].…”

Section: Smallanthus Sonchifolius Antidiabetic Potentialmentioning

confidence: 99%

Red Wine and Yacon as a Source of Bioactive Compounds with Antidiabetic and Antioxidant Potential

Nagalievska¹,

Sabadashka²,

Sybirna³

2021

Alternative Medicine - Update

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Phytochemicals derived from different plants are promising therapeutic agents. Herbal compounds can be used under diseases, etiological causes of which are alterations of carbohydrate, protein, and lipid metabolisms, along with increased oxidative stress and chronic low-grade inflammation. Potential sources of biologically active substances may be grape wine, rich in phenolic compounds. Well-studied examples of polyphenols are phenolic acids, catechins, anthocyanins, and flavonoids, etc. Another source of biologically active compounds is yacon (Smallanthus sonchifolius Poepp. & Endl.). The aboveground part of yacon is rich in phenolic compounds and terpenes. Main biologically active substances from tuberous roots of yacon are fructooligosaccharides and phenolic compounds. The section will be devoted to the analysis of hypoglycemic and antioxidant effects, and molecular targets of the complex of biologically active substances derived from red wine and yacon.

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“…Therefore, there is no conclusive information on the relationship between yacon consumption and its nutrigenomic value. Although the literature shows an association with the nutrigenomic properties [ 1 , 39 ], a causal relationship between yacon and observed health outcomes has not been firmly established. Similar to nutrigenomic properties reported in other plants [ 40 , 41 , 42 ], the findings of such studies on yacon should be interpreted with caution.…”

Section: Nutrigenomic Properties Of Yaconmentioning

confidence: 99%

Phytochemical Properties and Nutrigenomic Implications of Yacon as a Potential Source of Prebiotic: Current Evidence and Future Directions

Cao

Feei

Zhang

et al. 2018

Foods

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The human gut is densely populated with diverse microbial communities that are essential to health. Prebiotics and fiber have been shown to possess the ability to modulate the gut microbiota. One of the plants being considered as a potential source of prebiotic is yacon. Yacon is an underutilized plant consumed as a traditional root-based fruit in South America. Yacon mainly contains fructooligosaccharides (FOS) and inulin. Therefore, it has bifidogenic benefits for gut health, because FOS are not easily broken down by digestive enzymes. Bioactive chemical compounds and extracts isolated from yacon have been studied for their various nutrigenomic properties, including as a prebiotic for intestinal health and their antimicrobial and antioxidant effects. This article reviewed scientific studies regarding the bioactive chemical compounds and nutrigenomic properties of extracts and isolated compounds from yacon. These findings may help in further research to investigate yacon-based nutritional products. Yacon can be considered a potential prebiotic source and a novel functional food. However, more detailed epidemiological, animal, and human clinical studies, particularly mechanism-based and phytopharmacological studies, are lacking for the development of evidence-based functional food products.

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Safety assessment of aqueous extract from leaf Smallanthus sonchifolius and its main active lactone, enhydrin

Cited by 26 publications

References 23 publications

Polymatin A fromSmallanthus macroscyphusleaves: A safe and promising antidiabetic compound

Polymatin A fromSmallanthus macroscyphusleaves: A safe and promising antidiabetic compound

Red Wine and Yacon as a Source of Bioactive Compounds with Antidiabetic and Antioxidant Potential

Phytochemical Properties and Nutrigenomic Implications of Yacon as a Potential Source of Prebiotic: Current Evidence and Future Directions

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