Safety assessment of antibiotic administration by magnetic nanoparticles in in vitro zebrafish liver and intestine cultures

Chemello, Giulia; Randazzo, Basilio; Zarantoniello, Matteo; Fifi, Anna Paola; Aversa, Stefano; Ballarin, Cristina; Radaelli, Giuseppe; Magro, Massimiliano; Olivotto, Ike

doi:10.1016/j.cbpc.2019.108559

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…This aspect was recently evidenced by using fish organ cultures and testing different oxytetracycline exposure methods, including antibiotic bound on BIONs. Notably, the exposure of an isolated organ to BIONs bearing the antibiotic cannot be representative of the complexity of the interactions occurring in a whole organism [96].…”

Section: Bions For Biomedicinementioning

confidence: 99%

Bare Iron Oxide Nanoparticles: Surface Tunability for Biomedical, Sensing and Environmental Applications

Magro

Vianello

2019

Nanomaterials

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Surface modification is widely assumed as a mandatory prerequisite for the real applicability of iron oxide nanoparticles. This is aimed to endow prolonged stability, electrolyte and pH tolerance as well as a desired specific surface chemistry for further functionalization to these materials. Nevertheless, coating processes have negative consequences on the sustainability of nanomaterial production contributing to high costs, heavy environmental impact and difficult scalability. In this view, bare iron oxide nanoparticles (BIONs) are arousing an increasing interest and the properties and advantages of pristine surface chemistry of iron oxide are becoming popular among the scientific community. In the authors’ knowledge, rare efforts were dedicated to the use of BIONs in biomedicine, biotechnology, food industry and environmental remediation. Furthermore, literature lacks examples highlighting the potential of BIONs as platforms for the creation of more complex nanostructured architectures, and emerging properties achievable by the direct manipulation of pristine iron oxide surfaces have been little studied. Based on authors’ background on BIONs, the present review is aimed at providing hints on the future expansion of these nanomaterials emphasizing the opportunities achievable by tuning their pristine surfaces.

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Section: Bions For Biomedicinementioning

confidence: 99%

Bare Iron Oxide Nanoparticles: Surface Tunability for Biomedical, Sensing and Environmental Applications

Magro

Vianello

2019

Nanomaterials

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“…Zebrafish has a high degree of genetic homology with humans and is widely used to detect the toxicity of nanomaterials (Yang et al, 2018;Qiu et al, 2019). Previous studies showed that iron oxide nanoparticles could penetrate the chorion and act directly on the zebrafish embryos, leading to death, malformation, developmental delay, hatching failure, oxidative stress, and the alteration of redox homeostasis (Pitt et al, 2018;Chemello et al, 2019;Pereira et al, 2020;Thirumurthi et al, 2022). The accumulation of iron oxide nanoparticles in zebrafish larvae also caused the obvious cardiotoxicity, characterized by slowed heart rate, pericardial edema, and cardiac hemorrhage (Pereira et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptomics revealed neurodevelopmental impairments and ferroptosis induced by extremely small iron oxide nanoparticles

Lyu,

Kou,

et al. 2024

Front. Genet.

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Iron oxide nanoparticles are a type of nanomaterial composed of iron oxide (Fe3O4 or Fe2O3) and have a wide range of applications in magnetic resonance imaging. Compared to iron oxide nanoparticles, extremely small iron oxide nanoparticles (ESIONPs) (∼3 nm in diameter) can improve the imaging performance due to a smaller size. However, there are currently no reports on the potential toxic effects of ESIONPs on the human body. In this study, we applied ESIONPs to a zebrafish model and performed weighted gene co-expression network analysis (WGCNA) on differentially expressed genes (DEGs) in zebrafish embryos of 48 hpf, 72 hpf, 96 hpf, and 120 hpf using RNA-seq technology. The key hub genes related to neurotoxicity and ferroptosis were identified, and further experiments also demonstrated that ESIONPs impaired the neuronal and muscle development of zebrafish, and induced ferroptosis, leading to oxidative stress, cell apoptosis, and inflammatory response. Here, for the first time, we analyzed the potential toxic effects of ESIONPs through WGCNA. Our studies indicate that ESIONPs might have neurotoxicity and could induce ferroptosis, while abnormal accumulation of iron ions might increase the risk of early degenerative neurological diseases.

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Low toxicity of magnetite-based modified bionanocomposites with potential application for wastewater treatment: Evaluation in a zebrafish animal model

Guillén-Pacheco,

Ardila,

Peñaranda

et al. 2024

Chemosphere

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Safety assessment of antibiotic administration by magnetic nanoparticles in in vitro zebrafish liver and intestine cultures

Cited by 4 publications

References 46 publications

Bare Iron Oxide Nanoparticles: Surface Tunability for Biomedical, Sensing and Environmental Applications

Bare Iron Oxide Nanoparticles: Surface Tunability for Biomedical, Sensing and Environmental Applications

Comparative transcriptomics revealed neurodevelopmental impairments and ferroptosis induced by extremely small iron oxide nanoparticles

Low toxicity of magnetite-based modified bionanocomposites with potential application for wastewater treatment: Evaluation in a zebrafish animal model

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