Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity
Jia Liu,
Xin Ping,
Shu-jie Sun
et al.
Abstract:Introduction: Acori Tatarinowii Rhizoma (ATR) is a well-known traditional Chinese medicine that is used for treating neuropathic diseases. However, there is little information about the safety of ATR.Methods: The present study evaluated the acute and subacute oral toxicity of a water extract of ATR in Institute of Cancer Research (ICR) mice. In acute trials, a single administration of extract at a dose 5,000 mg/kg body weight led to no clinical signs of toxicity or mortality, indicating that the lethal dose (L… Show more
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