Safety assessment of a newly synthesized copolymer for micellar delivery of hydrophobic caffeic acid phenethyl ester

Development of herbal molecules in treating autoimmune uveitis: a narrative review

“…The CAPE delivery system showed no sign of toxicity. 67 CAPE has no detrimental effect on hematopoiesis or liver and renal function. Hence, CAPE is a non-toxic copolymer.…”

Functional Polyglycidol-Based Block Copolymers for DNA Complexation

“…The introduction of numerous hydroxyl groups enriches the possibilities for post-polymerization modification, but it is also manifested in the alteration of the properties of PG as compared to those of PEG. The hydroxyl groups were reported to promote the formation of a strongly hydrogen-bonded PG layer around hydrophobic domains of PG-based copolymers and non-phospholipid PG conjugates, which resulted in drastic changes in the aqueous solution properties and biological performance of these materials [38][39][40][41][42][43]. The present study aimed at evaluating the potential of copolymers based on linear polyglycidol to act as carriers of nucleic acids.…”

“…The present study aimed at evaluating the potential of copolymers based on linear polyglycidol to act as carriers of nucleic acids. From the library of PG-based copolymers studied earlier [38,[41][42][43], we selected diblock copolymers of polyglycidol and poly(allyl glycidyl ether) (PAGE) bearing C 12 hydrocarbon residue (hereinafter, C 12 -PAGE-PG). The PAGE moieties were modified by a thiol-ene click reaction to introduce a strong positive charge at each repeating unit.…”