Safety assessment and evaluation of probiotic potential of bacteriocinogenic Enterococcus faecium KH 24 strain under in vitro and in vivo conditions

Bhardwaj, Arun; Gupta, Hittu; Kapila, Suman; Kaur, Gurpreet; Vij, Shilpa; Malik, R. K.

doi:10.1016/j.ijfoodmicro.2010.05.001

Cited by 79 publications

(59 citation statements)

References 58 publications

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“…The same results were observed in E. faecium and E. faecium strains after incubation at pH 3.0 (Bhardwaj et al, 2010;Strompfová, Lauková, & Ouwehand, 2004). The Enterococcus strains can maintain difference between environmental and cytoplasmic pH via a unique homeostasis mechanism with a bilayer membrane structure; consequently, these strains can tolerate a wide range of pH (Musikasang, Tani, H-kittikun, & Maneerat, 2009).…”

Section: Discussionsupporting

confidence: 71%

Anti-proliferative effects of Enterococcus strains isolated from fermented dairy products on different cancer cell lines

Haghshenas

Nami

Abdullah

et al. 2014

Journal of Functional Foods

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Section: Discussionsupporting

confidence: 71%

Anti-proliferative effects of Enterococcus strains isolated from fermented dairy products on different cancer cell lines

Haghshenas

Nami

Abdullah

et al. 2014

Journal of Functional Foods

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“…A recent study demonstrated that the bacteriocin-producing strain Enterococcus faecium KH24 significantly affected the fecal microbiota of mice (3). In this study, mice received 10 8 CFU/day of bacteriocinogenic E. faecium KH24 (Bac ϩ ) and a nonbacteriocinogenic variant (Bac Ϫ ) for a period of 12 days.…”

Section: Bacteriocin Function: An Ecological Perspectivementioning

confidence: 98%

Bacteriocin Production: a Probiotic Trait?

Dobson

Cotter

Ross

et al. 2012

Appl Environ Microbiol

550

368

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Bacteriocins are an abundant and diverse group of ribosomally synthesized antimicrobial peptides produced by bacteria and archaea. Traditionally, bacteriocin production has been considered an important trait in the selection of probiotic strains, but until recently, few studies have definitively demonstrated the impact of bacteriocin production on the ability of a strain to compete within complex microbial communities and/or positively influence the health of the host. Although research in this area is still in its infancy, there is intriguing evidence to suggest that bacteriocins may function in a number of ways within the gastrointestinal tract. Bacteriocins may facilitate the introduction of a producer into an established niche, directly inhibit the invasion of competing strains or pathogens, or modulate the composition of the microbiota and influence the host immune system. Here we review the role of bacteriocin production in complex microbial communities and their potential to enhance human health.

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“…Antagonistic activity of the bacteriocin producers against a number of pathogenic or antibiotic-resistant bacterial strains in the gut has been a major focus of gut microbiota studies. Several LAB bacteriocins and/or bacteriocin-producing LAB have been shown to inhibit pathogens such as Listeria monocytogenes [83,84], Clostridium difficile [85–87], Staphylococcus aureus [88] and even Salmonella enteritidis [89], Some bacteriocin producers have also been reported to eliminate multidrug- or vancomycin-resistant enterococci [81,90]. Therefore, the production of bacteriocins may contribute to the beneficial activities in the gut.…”

Section: Bacteriocinsmentioning

confidence: 99%

Modulation of the gut microbiota by prebiotic fibres and bacteriocins

Umu

Rudi

Diep

2017

Microbial Ecology in Health and Disease

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The gut microbiota is considered an organ that co-develops with the host throughout its life. The composition and metabolic activities of the gut microbiota are subject to a complex interplay between the host genetics and environmental factors, such as lifestyle, diet, stress and antimicrobials. It is evident that certain prebiotics, and antimicrobials produced by lactic acid bacteria (LAB), can shape the composition of the gut microbiota and its metabolic activities to promote host health and/or prevent diseases. In this review, we aim to give an overview of the impact of prebiotic fibres, and bacteriocins from LAB, on the gut microbiota and its activities, which affect the physiology and health of the host. These represent two different mechanisms in modulating the gut microbiota, the first involving exploitative competition by which the growth of beneficial bacteria is promoted and the latter involving interference competition by which the growth of pathogens and other unwanted bacteria is prevented. For interference competition in the gut, bacteriocins offer special advantages over traditional antibiotics, in that they can be designed to act towards specific unwanted bacteria and other pathogens, without any remarkable collateral effects on beneficial microbes sharing the same niche.

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Safety assessment and evaluation of probiotic potential of bacteriocinogenic Enterococcus faecium KH 24 strain under in vitro and in vivo conditions

Cited by 79 publications

References 58 publications

Anti-proliferative effects of Enterococcus strains isolated from fermented dairy products on different cancer cell lines

Anti-proliferative effects of Enterococcus strains isolated from fermented dairy products on different cancer cell lines

Bacteriocin Production: a Probiotic Trait?

Modulation of the gut microbiota by prebiotic fibres and bacteriocins

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