Safety aspects of natural food additives frequently used at their maximum levels in South Korea

Yoo, Na-Kyung; Kim, Ye-Hyun; Choi, Soo‐Jin

doi:10.1007/s13273-021-00191-0

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…As the consumption of meat and meat products increases with rising populations and income levels, their quality has become just as important as their quantity [1]. Consequently, food safety is a main concern for consumers, policy makers, producers, and meat processors [2,3]. In general, antibiotics are used to improve livestock productivity, enhance feed efficiency, and prevent and treat livestock diseases [4,5].…”

Section: Introductionmentioning

confidence: 99%

Establishment of the Maximum Residual Limit in the Milk of Dairy Cows Injected Intramuscularly with Prednisolone

Rha,

Yang,

Kim

et al. 2023

Veterinary Sciences

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We measured the levels of prednisolone (PSL) residues in milk of intramuscularly dosed dairy cows and established a withdrawal time (WT) of PSL in milk. Eight healthy Holstein cows were injected with 10 (PSL-1) or 20 (PSL-2) mL of 10 mg/mL of PSL, and then, their milk was sampled at 12 h intervals for five days. PSL residue concentrations in milk were determined using LC-MS/MS. The correlation coefficient of the calibration curve was 0.9976. The limit of detection (LOD) and the limit of quantification (LOQ) were 0.2 µg/kg and 0.6 μg/kg, respectively. Recoveries ranged from 96.5% to 110.0%, and the coefficient of variation was <5.64%. At 24 h after administration, PSL levels in PSL-1 and PSL-2 were below the LOQ in all milk samples. Although this study had a smaller sample size than the European Medicines Agency’s recommendations (n = 20), it was based on the Animal and Plant Quarantine Agency guidelines of the Republic of Korea (n = 8) for the determination of withdrawal periods in milk. We established the withdrawal period for both PSL-1 and PSL-2 in milk at 12 h. In conclusion, we developed an analytical method that is sensitive and can reliably detect PSL in milk, and our estimated WT of PSL in bovine milk is shorter than the current 3-day withdrawal period of PSL in commercial PSL products.

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