Safety and value of skin test to sex hormones and sex hormone sensitivity desensitization in women with premenstrual syndrome

Itsekson, Alek M.; Yonit, Bomstein; Matitiyahu, Zolti; Kivity, Shmuel

doi:10.1016/j.waojou.2019.100041

Cited by 4 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Today there is the opinion that the hypersensitivity of the organisms to the female steroid hormones may explain the reaction of organisms to their changes during the menstrual cycle on the background of normal hormonal concentration [25]. Itsekson AM et al found the positive correlation between skin sensitivity to progesterone and estrogens and PMS and the authors proposed desensitization procedure to relive the severity of clinical manifestation of the syn- drome [26]. Besides this, the cytokine factors can lead to different mood problems [27].…”

Section: Discussionmentioning

confidence: 99%

Estradiol Blood Level and Esr1 Gene Polymorphism in Women With Premenstrual Syndrome

et al. 2020

View full text Add to dashboard Cite

The aim: To evaluate the association between estrogen receptor (ESR1) α- Xbal polymorphism with estradiol serum blood level in the patients with premenstrual syndrome. Materials and methods: 50 women with premenstrual syndrome and 20 controls were examined. The level of estradiol was measured in the blood serum in both phases of the menstrual cycle by ELISA method. Polymerase chain reaction was used to study ESR1 gene polymorphism (A-351G variant). Results: The estradiol concentration was similar in two phases of the menstrual cycle between healthy women and patients with premenstrual syndrome. But the more growth of estradiol in the luteal phase was determined in the persons with premenstrual syndrome. The rate of GG genotype was the largest in women with severe premenstrual syndrome (χ2=3.52, p=0.06). Also, in the persons with severe premenstrual syndrome who had G allele (GG+AG genotype) the estradiol concentration in the luteal phase of the menstrual cycle was on 50.00 % (p=0.02) higher compared to carriers of AA genotype. There was no difference in estradiol level between healthy women with GG+AG genotype and AA genotype. Conclusions: AG polymorphism of ESR1 gene may be the marker of development of premenstrual syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Estradiol Blood Level and Esr1 Gene Polymorphism in Women With Premenstrual Syndrome

et al. 2020

View full text Add to dashboard Cite

show abstract

“…At present, the pathophysiology of PMS is still unclear. Some researchers believe that the fluctuation of female reproductive hormones can lead to PMS [16]. Some people think that the secretion of some neurotransmitters, such asγ -aminobutyric acid and catecholamine, leads to PMS [17,18].…”

Section: Introductionmentioning

confidence: 99%

Effects of electroacupuncture on the premenstrual syndrome: A randomized clinical trial

Kuang¹,

Lin²,

Zhang³

et al. 2021

J Clin Images Med Case Rep

View full text Add to dashboard Cite

Objective: The purpose of this study was to evaluate the effect and possible mechanism of electroacupuncture on Premenstrual Syndrome (PMS). Method: From May 2018 to December 2018, 60 participants who met the criteria were selected and divided randomly into either the Electroacupuncture (EA) group or the Placebo (PA) group. Three courses of treatment were provided. During the treatment, the main symptoms and signs of moderate and severe PMS in each menstrual cycle were recorded by filling in DRSP, HAMA, and HAMD. The hormone levels were detected in the luteal phase. Results: Compared with the PA group, the scores of symptoms and sign dimension and influence dimension changed significantly from the first cycle in the EA group; the scores of emotion dimension and the total score changed significantly from the second cycle in the EA group. The total effective rate of the EA group was significantly higher than that of the PA group. The level of Progesterone (P) and allopregnanolone increased significantly in the EA group. 1,25-(OH)2D decreased significantly in the EA group after treatment. Corticotropin Releasing Hormone (CRH) and Adrenocorticotropic Hormone (ACTH) decreased significantly in the EA group after treatment. Dopamine (DA), 5-Hydroxytryptamine (5-HT), Noradrenaline (NA), beta Endorphin (β-EP), Gamma Aminobutyric Acid (GABA), Glutamate (Glu) and Glu/GABA changed significantly in the EA group after treatment. Prostaglandin F2α (PGF2α) and Prostaglandin E2 (PGE2) had significant changes after treatment in the EA group. Conclusion: Electroacupuncture is effective to treat PMS, which may be alleviated by regulating P, allopregnanolone, 1,25-(OH)2D, CRH, ACTH, 5-HT, DA, NA, β – EP, GABA, Glu, Glu/GABA, PGF2 α and PGE2. Keywords: Premenstrual syndrome; electroacupuncture; DRSP; serum hormone.

show abstract

Diagnostic and therapeutic use of oral micronized progesterone in endocrinology

Memi,

Pavli,

Papagianni

et al. 2024

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Progesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; regulates normal menstrual bleeding; contributes to fertilization and pregnancy maintenance; participates in the onset of labor. In addition, it exerts numerous effects on other endocrine systems. Micronized progesterone (MP) is natural progesterone with increased bioavailability, due to its pharmacotechnical micronized structure, which makes it an attractive diagnostic and therapeutic tool. This critical literature review aims to summarize and put forward the potential diagnostic and therapeutic uses of MP in the field of endocrinology. During reproductive life, MP is used for diagnostic purposes in the evaluation of primary or secondary amenorrhea as a challenge test. Moreover, it can be prescribed to women presenting with amenorrhea or oligomenorrhea for induction of withdrawal bleeding, in order to time blood-sampling for diagnostic purposes in early follicular phase. Therapeutically, MP, alone or combined with estrogens, is a useful tool in various endocrine disorders including primary amenorrhea, abnormal uterine bleeding due to disordered ovulation, luteal phase deficiency, premenstrual syndrome, polycystic ovary syndrome, secondary amenorrhea [functional hypothalamic amenorrhea, premature ovarian insufficiency], perimenopause and menopause. When administrated per os, acting as a neurosteroid directly or through its metabolites, it exerts beneficial effects on brain function such as alleviation of symptoms of anxiety and depression, asw well as of sleep problems, while it improves working memory in peri- and menopausal women. Micronized progesterone preserves full potential of progesterone activity, without presenting many of the side-effects of progestins. Although it has been associated with more frequent drowsiness and dizziness, it can be well tolerated with nocturnal administration. Because of its better safety profile, especially with regard to metabolic ailments, breast cancer risk and veno-thromboembolism risk, MP is the preferred option for individuals with an increased risk of cardiovascular and metabolic diseases and of all-cause mortality.

show abstract

Safety and value of skin test to sex hormones and sex hormone sensitivity desensitization in women with premenstrual syndrome

Cited by 4 publications

References 19 publications

Estradiol Blood Level and Esr1 Gene Polymorphism in Women With Premenstrual Syndrome

Estradiol Blood Level and Esr1 Gene Polymorphism in Women With Premenstrual Syndrome

Effects of electroacupuncture on the premenstrual syndrome: A randomized clinical trial

Diagnostic and therapeutic use of oral micronized progesterone in endocrinology

Contact Info

Product

Resources

About