Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers

Cammu, Guy; Kam, P.J. de; Demeyer, Ignace; Decoopman, M.; Peeters, Pierre; Smeets, J. W. H.; Foubert, L.

doi:10.1093/bja/aem402

Cited by 86 publications

(68 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Comparing sugammadex to neostigmine it is known to more quickly reverse the neuromuscular block produced by rocuronium under general anesthesia 20 . Cammu et al 21 in a study of healthy volunteers used sugammadex after a single dose of rocuronium and vecuronium and observed important changes in vital signs on ECG. In another study it was determined that sugammadex with a dose of 1-8 mg/ kg minimally affected the QT c interval 3 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

et al. 2014

View full text Add to dashboard Cite

PURPOSE:To compare the effects of sugammadex and neostigmine, used to antagonize the effects of rocuronium, on the QT c interval. METHODS:This study used 10 adult New Zealand white rabbits of 2.5-3.5 kg randomly divided into two groups: sugammadex group (Group S, n:5) and neostigmine group (Group N, n:5). For general anesthesia administering 2 mg/kg iv propofol and 1 mcg/ kg iv fentanyl, 0.6 mg/kg iv rocuronium was given. Later to provide reliable airway for all experimental animals V-Gel Rabbit was inserted. The rabbits were manually ventilated by the same anesthetist. After the V-Gel Rabbit was inserted at 2,5,10,20, 25, 27, 30 and 40 minutes measurements were repeated and recorded. At 25 minutes after induction Group N rabbits were given 0.05 mg/kg iv neostigmine + 0.01 mg/kg iv atropine. Group S were administered 2 mg/kg iv sugammadex. RESULTS:Comparing the QT c interval in the rabbits in Group S and Group N, in the 25th, 27th and 30th minute after muscle relaxant antagonist was administered the QT c interval in the neostigmine group rabbits was significantly increased (p<0.05). CONCLUSION:While sugammadex, administered to antagonize the effect of rocuronium, did not significantly affect the QT c interval, neostigmine+atropine proloned the QT c interval.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

et al. 2014

View full text Add to dashboard Cite

show abstract

“…3 Vecuronium has a 3-fold lower affinity for sugammadex than does rocuronium. 4 Higher doses of sugammadex are likely to be necessary to Volume 51, July-August 2016 reverse pancuronium. 6 Muscle relaxants from the benzylisoquinoline group (eg, cisatracurium, mivacurium) fit poorly or not at all.…”

Section: Clinical Pharmacologymentioning

confidence: 99%

“…7,8,10 Rocuronium and vecuronium plasma concentrations decline more rapidly than do those of sugammadex. 4 The half-life of sugammadex in patients with mild, moderate, and severe renal impairment is 4, 6, and 19 hours, respectively. 1 In patients with severe renal function impairment, exposure to sugammadex was prolonged and was 17-fold higher.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Sugammadex

Cada¹,

Levien

Baker

2016

Hosp Pharm

View full text Add to dashboard Cite

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, contact Wolters Kluwer customer service at 866-397-3433. The July 2016 monograph topics are pimavanserin, venetoclax, defibrotide, liftegrast ophthalmic solution 5%, and atezolizumab. The Safety MUE is on pimavanserin.

show abstract

“…Curarization is particularly dangerous for patients with CNS pathologies in which consciousness and protective reflexes can be compromised due to the underlying disease or the neurosurgical intervention. The administration of sugammadex at a suitable dose enables the reversal of neuromuscular block irrespective of its depth and has none of the side effects associated with acetylcholinesterase inhibitors [5].…”

mentioning

confidence: 99%

Zastosowanie sugammadeksu do odwracania bloku nerwowo-mięśniowego wywołanego wekuronium po operacjach wewnątrzczaszkowych

Karwacki¹,

Niewiadomski²,

Rzaska³

2015

Anaesthesiol Intensive Ther

View full text Add to dashboard Cite

Background: Total intravenous anaesthesia with propofol and remifentanil is widely used in neuroanaesthesiology and enables the quick recovery and early neurological assessment of patients. The administration of muscle relaxants carries a risk of residual relaxation following surgery. The administration of a suitable dose of sugammadex reverses the neuromuscular block irrespective of its depth and has none of the side effects associated with acetylcholinesterase inhibitors. The aim of the present study was to evaluate the usefulness of sugammadex for the reversal of vecuroniuminduced effects following intracranial surgery. Method: The study involved 38 women who underwent supratentorial tumour removal. These women were randomly divided into two groups. Total intravenous anaesthesia with propofol and remifentanil using target-controlled infusion was administered according to the Schnider and Minto models, respectively. Endotracheal intubation was performed after the target concentrations of propofol and remifentanil reached 4 µg mL -1 and 4 ng mL -1 , respectively. Vecuronium (100 µg kg -1 ) was administered, and no response to TOF stimulation was observed. Relaxation was continued via the continuous infusion of vecuronium (0.8-1.2 µg kg -1 min -1 ) to provide a TOF of 2 throughout the surgery. In group I, neuromuscular conduction was restored with intravenous sugammadex (2 mg kg -1 ), whereas in group II, no reversal agents were administered. Results: The times of the return of spontaneous breathing, extubation, eye opening (both spontaneous and in response to a verbal command) were found to be longer in group II than group I. Conclusion: The use of sugammadex following craniotomy accelerates the achievement of optimal extubation conditions.

show abstract

Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers

Cited by 86 publications

References 11 publications

Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

Sugammadex

Zastosowanie sugammadeksu do odwracania bloku nerwowo-mięśniowego wywołanego wekuronium po operacjach wewnątrzczaszkowych

Contact Info

Product

Resources

About