Safety and Tolerability of 120 mg/kg Dose of Alpha1-Proteinase Inhibitor in Alpha-1 Antitrypsin Deficiency: A Multicenter, Randomized, Double-Blind, Crossover Study

Alpha 1 antitrypsin deficiency: a rare multisystem disease, predominantly affecting the lung

“…protective threshold was conducted by Wewers et al and adopted a treatment dose of 60mg/kg weekly(59). Although there have been several studies exploring different treatment doses at different frequencies of administration(60)(61)(62), the treatment regimen in clinical practice has remained 60mg/kg/week. When augmentation therapy was first introduced as a treatment, the measurement standards available to evaluate decline in lung function associated with AATD were based on little empirical data.…”