Safety and Therapeutical Benefit of Hemicraniectomy Combined with Mild Hypothermia in Comparison with Hemicraniectomy Alone in Patients with Malignant Ischemic Stroke

Abstract

Introduction: Both for hemicraniectomy and for hypothermia, several reports describe a beneficial effect in patients with malignant supratentorial cerebral ischemia. We compared the safety and the clinical outcome in patients with a malignant supratentorial infarction who were treated with hemicraniectomy alone (HA) or received a combination therapy with hemicraniectomy and hypothermia of 35°C (HH), respectively. Methods: In a prospective and randomized study, 25 consecutive patients were treated after an ischemic infarction of more than two thirds of one hemisphere by HA (n = 13 patients) or the HH combination therapy (n = 12 patients). Safety parameters were compared between both treatment groups, the clinical outcome was assessed during treatment and after 6 months. Results: Age, cranial CT or MRI findings, initial National institutes of Health Stroke Scale Score (NIHSSS) and level of consciousness were not significantly different between both groups. Hemicraniectomy was performed within 15 ± 6 h after the ischemic event. Hypothermia was induced immediately after surgery. Overall mortality was 12% (2/13 vs. 1/12 in the two groups), but none of these 3 patients died due to treatment-related complications. There were no severe side effects of hypothermia. Duration of need for intensive care or for mechanical ventilation and infectious status did not differ significantly between both groups, but the need for catecholamine application was increased in the HH group. The clinical outcome showed a tendency for a better outcome in the HH compared with the HA group with respect to status after 6 months, as assessed by the NIHSSS (10 ± 1 vs. 11 ± 3, p < 0.08). Discussion: The present study suggests that a combined therapy of mild hypothermia and hemicraniectomy in malignant brain infarction does not imply additional risks by side effects and improves functional outcome as compared with hemicraniectomy alone.

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke

“…A single-center, randomized clinical study of 25 patients demonstrated a better 6-month functional outcome on the NIHSS in patients treated with hypothermia and hemicraniectomy than in those with normothermia after hemicraniectomy. 37 Lower rates of hemorrhagic transformation and malignant cerebral edema have also been reported in another series of 75 patients. 62 Conversely, the Intravascular Cooling in the Treatment of Stroke (ICTuS) study was a Phase I trial evaluating the effect of inducing intravascular hypothermia within 6 hours of stroke onset.…”

Decompressive craniotomy in patients with intracranial aneurysmal hemorrhage

“…Применение ДТЧ в лечении больных с тяжелыми аневризматическими кровоизлияниями основано на по-ложительном опыте использования этой операции при ВЧГ у больных с черепно-мозговой травмой и у пациентов с ишемическим инсультом, который по патогенезу наи-более близок к таким осложнениям аневризматического кровоизлияния, как ангиоспазм и его последствия [29][30][31][32][33][34][35][36]. Положительный эффект ДТЧ при церебральной ише-мии обусловлен существенным снижением ВЧД, увеличе-нием оксигенации мозговой ткани и улучшением показа-телей цереброваскулярной реактивности [13].…”

Therapeutic Hypothermia in Acute Stroke

“…[62] Hemicraniectomy was performed within 15 +/-6 h after the ischemic event, followed by hypothermia. There were no severe side effects of hypothermia.…”

“…[14] Trials using milder hypothermia [35°C) and slower rewarming periods have reported lower complication rates. [62] For practical purposes, a 24-hour cooling period followed by a >12-hour slow rewarming, such as 0.1° C/h is advised. [82] …”