Safety and therapeutic efficacy of undenatured type‐ii collagen (UC‐II) in comparison to glucosamine and chondroitin in arthritic horses

Gupta, Ramesh C.; Bagchi, Debasis; Skaggs, P.; Stocker, A.; Wegford, K.; Goad, John T.; Canerdy, T. D.; Bagchi, Manashi; Barnett, Dale; DeWees, Wiliam

doi:10.1111/j.1439-0396.2009.00921_3.x

Cited by 2 publications

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“…Previous research has shown undenatured type II collagen supplementation to improve knee extension range of motion in healthy individuals with exercise-induced knee pain [9]. Similar bene ts have been reported in animal studies, with both arthritic dogs [10] and arthritic horses [11] showing reduced pain during joint manipulation following supplementation periods with undenatured type II collagen.…”

Section: Introductionsupporting

confidence: 57%

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Efficacy of UC‐II® undenatured type II collagen on knee joint function in healthy subjects: an exploratory post hoc analyses of a randomized double blind, placebo ‐ controlled trial

Saiyed

Durkee

Bowman³

et al. 2021

FASEB j.

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Background UC‐II® brand collagen is a unique joint health ingredient derived from chicken sternum. In a previous study, UC‐II® collagen was shown to improve knee joint function in healthy subjects (≥30 to ≤65 y) as demonstrated by greater knee extension range of motion. The same study showed that subjects consuming UC‐II® collagen were able to exercise longer than pre‐supplementation values. Objective The purpose of the current exploratory analyses was to assess the select items from the Knee Injury and Osteoarthritis Outcome Score (KOOS) in healthy subjects who previously participated in a 120‐day randomized controlled trial and were aged greater or equal than 50 years. Methods A total of 18 subjects met the analyses criteria (age ≥50 years). These healthy subjects reported knee pain after participating in a standardized stepmill test and were randomized to receive placebo (n = 8) or the UC‐II® (40 mg daily, n = 10) product for 120 days. KOOS survey results were collected at different time points during the study. The KOOS survey is a validated instrument consisting of multiple questions that are classified into sub‐scales such as pain, other symptoms, function in daily living, function in sport and recreation, and knee related quality of life. It measures the subjects’ opinion about their knees and their ability to perform daily activities during the past week. The KOOS survey is useful for assessing changes in knee pathology over time, with or without treatment. Statistical software SAS release 8.2 (SAS Institute Inc., Cary, NC) was used for the analyses. The intent‐to‐treat analysis was conducted between the treatment and within groups. P‐values ≤0.05 were considered statistically significant. Results After 120 days of supplementation, subjects in the UC‐II® group exhibited a statistically significant improvement versus the placebo in KOOS items which include reduced pain during standing upright and going up or down stairs, decreased discomfort in climbing ascending stairs or bending to floor to pick an object or squatting during period of high physical activity (p<0.05). Conclusion Results of this post hoc analysis suggest that UC‐II® collagen supplementation has the potential to improve knee joint function, mobility, flexibility, free movements and performance of daily activities in ≥ 50 year old healthy subjects.

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Section: Introductionsupporting

confidence: 57%

“…UC-II® is a unique nutritional supplement that has demonstrated support for joint health in humans [9] and animals [10,11]. In the current report, daily supplementation (40mg) of undenatured type II collagen for 120 days prompted signi cant improvements in KOOS survey scores compared to placebo in a cohort…”

Section: Discussionmentioning

confidence: 87%

Efficacy of UC‐II® undenatured type II collagen on knee joint function in healthy subjects: an exploratory post hoc analyses of a randomized double blind, placebo ‐ controlled trial

Saiyed

Durkee

Bowman³

et al. 2021

FASEB j.

View full text Add to dashboard Cite

show abstract

Efficacy of UC-II® Undenatured Type II Collagen on Knee Joint Function in Healthy Subjects: an Exploratory Post Hoc Analysis of a Randomized, Double-blind, Placebo-controlled Trial

Saiyed

Durkee

Bowman

et al. 2021

Preprint

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BackgroundUC-II® is a unique joint health ingredient derived from chicken sternum. In a previous study, UC-II® improved knee extension range of motion and extend exercise time before the onset of knee pain in healthy participants. MethodsThe current exploratory post hoc analyses sought to assess items from the Knee Injury and Osteoarthritis Outcome Score (KOOS) in healthy participants aged ≥50 years who previously participated in a randomized controlled trial. All participants reported knee pain following a standardized stepmill test and were randomized to receive placebo or 40 mg UC-II® supplementation containing ≥ 3% (≥ 1.2 mg) undenatured type II collagen for 120 days. For the current post hoc analyses, 17 participants (UC-II® = 9, placebo = 8) met the acceptance criteria (age ≥ 50 years). Analysis was carried out for the KOOS survey results with modified intent-to-treat analysis (mITT). P-values ≤0.05 were considered statistically significant. ResultsAfter 120 days of supplementation, participants in the UC-II® supplementation group exhibited statistically significant improvements versus the placebo in select KOOS items including reduced pain during standing upright and going up or down stairs, decreased discomfort in climbing ascending stairs or bending to floor to pick an object, or squatting during physical activity (p<0.05). ConclusionUC-II® supplementation has the potential to improve knee joint function, mobility, flexibility, free movements and performance of daily activities in healthy participants ≥ 50 years old with exercise-induced knee pain.

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Safety and therapeutic efficacy of undenatured type‐ii collagen (UC‐II) in comparison to glucosamine and chondroitin in arthritic horses

Cited by 2 publications

References 0 publications

Efficacy of UC‐II® undenatured type II collagen on knee joint function in healthy subjects: an exploratory post hoc analyses of a randomized double blind, placebo ‐ controlled trial

Efficacy of UC‐II® undenatured type II collagen on knee joint function in healthy subjects: an exploratory post hoc analyses of a randomized double blind, placebo ‐ controlled trial

Efficacy of UC-II® Undenatured Type II Collagen on Knee Joint Function in Healthy Subjects: an Exploratory Post Hoc Analysis of a Randomized, Double-blind, Placebo-controlled Trial

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