Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, first-in-man BIOSOLVE-I trial

Haude, Michael; Erbel, Raimund; Erné, Paul; Verheye, Stefan; Degen, Hubertus; Böse, Dirk; Vermeersch, Paul; Wijnbergen, Inge; Weissman, Neil J.; Prati, Francesco; Waksman, Ron; Koolen, Jacques

doi:10.1016/s0140-6736(12)61765-6

Cited by 346 publications

(200 citation statements)

References 29 publications

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“…12 Uma vez que a retração aguda é resultante do equi líbrio entre o recuo elástico da parede vascular e a força radial exercida pelo stent, ela pode ser alterada por características da lesão ou do próprio procedimento, como o diâmetro de referência do vaso, a pressão má-xima de inflação do balão e o superdimensionamento do stent utilizado. Em relação ao diâmetro do vaso e a pressão máxima de inflação do balão, não houve diferença nas taxas de retração entre os três grupos.…”

Section: Discussionunclassified

Comparação da retração aguda do stent entre o suporte vascular bioabsorvível eluidor de everolimus e dois diferentes stents metálicos farmacológicos

Borghi¹,

Costa²,

Abizaid³

et al. 2013

Rev. Bras. Cardiol. Invasiva

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Section: Discussionunclassified

Comparação da retração aguda do stent entre o suporte vascular bioabsorvível eluidor de everolimus e dois diferentes stents metálicos farmacológicos

Borghi¹,

Costa²,

Abizaid³

et al. 2013

Rev. Bras. Cardiol. Invasiva

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“…Moreover, magnesium-based metallic bioresorbable scaffolds were developed in order to ensure mechanical characteristics of a classic DES. After the initial discouraging results, the DREAMS 1G ® (paclitaxel-eluting) and the DREAMS 2G ® (sirolimus-eluting) scaffolds yielded promising results, as in BIOSOLVE II study (23,24).…”

Section: Absorb Bvs In Various Clinical Settingsmentioning

confidence: 99%

Bioresorbable vascular scaffolds—what does the future bring?

Bil¹,

Gil²

2016

J. Thorac. Dis.

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“…[ 50,51 ] Indeed, a drug-eluting, absorbable magnesium stent, and absorbable bone screws are now commercially available, and have both been the recent subjects of positive clinical human trials. [ 52,53 ] …”

Section: Magnesium As a Biomaterialsmentioning

confidence: 99%

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

et al. 2016

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Their inherent lack of dislocations and hence slip planes leads to exceptionally high strength and elasticity, approaching the theoretical limit. While oxide glasses and ceramics exhibit low toughness and brittle failure, BMGs can display toughness comparable to crystalline metals. [ 2 ] The lack of grain structure means that BMGs are homogeneous and exhibit isotropic behavior, even at sub-micrometer length scales, and, without grain boundaries or precipitates as oxidation sites, corrosion rates are significantly reduced compared to conventional metals.BMGs soften above an alloy-specifi c glass-transition temperature ( T g ) before eventual, time-dependent, crystallization at a higher, crystallization temperature ( T x ). In this supercooled liquid region (SCLR) between T g and T x , the viscous BMGs may be plastically shaped under low applied forces using polymer-processing techniques, such as hot embossing, extrusion, foaming, and injection and blow moulding, before again cooling to a solid metallic glass. With relatively low processing temperatures and no solidifi cation shrinkage, parts can be formed to netshape with excellent accuracy, and geometries, and surface patterns previously diffi cult in metals can be achieved with ease. [3][4][5][6][7] Such remarkable properties and behavior have led to significant interest in BMGs as engineering materials over the past 20 years, but it is only recently that their potential for use as a biomaterial has been studied. [ 8 ] To date, our understanding of material biocompatiblity has evolved mainly through empirical testing, observing the interaction of materials with cells and host tissue in vitro and in vivo. Materials can induce host responses varying from local and systemic infl ammation, hypersensistivity, toxicity, and even tumorogenesis, meaning that thorough evidence of material safety is required before regulatory approval and clinical translation. We now largely recognise the material characteristics that generate both favorable and undesired host responses, as outlined by Williams, [ 9 ] offering the opportunity for informed material design, while being cognisant that biocompatibility is specifi c to the application and host environment. [ 10 ] The original requirement of fi rst generation "biocompatible" materials was bio-inertness. [ 11 ] This included a resistance to corrosion in the body, and here Ti-and Co-based alloys scored highly. [ 12 ] Less-inert metals, such as Mg, were therefore not deemed suitable, although the ions released on dissolution are generally not harmful to the human body. However, current design requirements for biomaterials, including most recently biometals, include eliciting an appropriate host response, [ 13 ] and this can include the need to biodegrade and resorb. There are potential advantages for BMGs that span applications of With increasing knowledge of the materials science of bulk metallic glasses (BMGs) and improvements in their properties and processing, they have started to become candidate materials for biomedical dev...

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Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, first-in-man BIOSOLVE-I trial

Cited by 346 publications

References 29 publications

Comparação da retração aguda do stent entre o suporte vascular bioabsorvível eluidor de everolimus e dois diferentes stents metálicos farmacológicos

Comparação da retração aguda do stent entre o suporte vascular bioabsorvível eluidor de everolimus e dois diferentes stents metálicos farmacológicos

Bioresorbable vascular scaffolds—what does the future bring?

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

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