“…The ATP deficit due to the action of 3 BP prevents full operation of the efflux pumps, which are not able to pump out of the cells large quantities of the following agents: cisplatin, doxorubicin, 5‐fluorouracil, paclitaxel, epirubicin, daunorubicin, and mitoxantrone (Rello et al, ; Sánchez‐Aragó & Cuezva, ; Wu et al, ). Moreover, previous studies showed that 3 BP acts synergistically with compounds, which are GSH‐depleting agents such as buthionine sulfoximine, methionine sulfoximine, and acetaminophen (El Sayed et al, ; El Sayed, Baghdadi, Almaramhy, Ayat, & Donki, ; Garbutcheon‐Singh, Harper, & Aldrich‐Wright, ; Lee et al, ; Lis, Dyląg, et al, ; Majkowska‐Skrobek et al, ; Niedźwiecka et al, ). Drugs used in the treatment of MM cause accumulation of toxicity in organisms and consequently numerous side effects (Benboubker et al, ).…”