Safety and indication of surgical treatment for elderly patients with gallbladder carcinoma

Abstract

Report of a rare case of synchronic common bile duct tumors, adenocarcinoma and large cell neuroendocrine tumor in a 51 year old man, with classical findings of distal bile duct malignancy which after a apparently successful radical surgery had a very complicated follow up with early aggressive metastatic disease recurrence. Conclusion: Even with the increasing number of bile duct adenocarcinoma diagnosis, it is still a rare cause of digestive tract malignancy. The concomitance of adenocarcinoma with NET in the extrahepatic bile duct makes this case unique.

Prognostic role of the controlling nutritional status (CONUT) score in patients with biliary tract cancer: a meta-analysis

“…Table 2 displays fundamental features of the included articles [ 17–26 ]. Six studies were performed in Japan [ 18 , 19 , 23–26 ] and four in China [ 17 , 20–22 ]. The sample size of these studies ranged from 45 to 371, with the median value of 121.5.…”

“…All studies used a retrospective design. Four articles included ECC cases [ 17 , 20 , 23 , 25 ]; three, ICC cases [ 18 , 21 , 24 ]; two, BTC cases [ 22 , 26 ]; and one, GBC cases [ 19 ]. Nine studies treated patients with surgical resection [ 18–26 ], and one study adopted percutaneous transhepatic biliary stenting (PTBS) plus 125I seed intracavitary irradiation [ 17 ].…”

“…Nine studies treated patients with surgical resection [ 18–26 ], and one study adopted percutaneous transhepatic biliary stenting (PTBS) plus 125I seed intracavitary irradiation [ 17 ]. Five studies used ≥3 as the cut-off value for CONUT [ 19–21 , 23 , 25 ], four studies selected ≥2 [ 17 , 18 , 22 , 24 ], and one study adopted ≥4 [ 26 ]. All 10 studies mentioned the role of CONUT in predicting overall survival (OS) in BTC [ 17–26 ].…”

“…Previous studies have analyzed whether the CONUT score could be adopted to predict the prognosis of patients with BTC, but their findings have been inconsistent [ 17–26 ]. For instance, some studies have shown that the CONUT score is important for predicting BTC prognosis [ 19 , 20 , 23 , 26 ], whereas others have suggested that CONUT score is not related to BTC prognosis [ 21 , 24 ]. Therefore, the present meta-analysis reviewed the most recent data to identify the significance of the CONUT score in predicting the prognosis of patients with BTC.…”

Effects of cytoreductive surgery combined with hyperthermic perfusion chemotherapy on prognosis of patients with advanced gallbladder cancer

“…Therefore, the prognosis is usually unfavorable, and the overall five-year survival rate is < 5%[ 4 ]. In cases of tumor recurrence, systemic therapy can be selected based on pathological characteristics to prolong survival time[ 5 ]. Therefore, close postoperative follow-up is crucial.…”