Safety and efficacy of whole-body chlorhexidine gluconate cleansing with or without emollient in hospitalised neonates (NeoCHG): a multicentre, randomised, open-label, factorial pilot trial

Russell, Neal; Clements, Michelle N.; Azmery, Kazi Shammin; Bekker, Adrie; Bielicki, Julia; Dramowski, Angela; Ellis, Sally; Fataar, Aaqilah; Hoque, Mahbubul; LeBeau, Kristen; O’Brien, Seamus; Schiavone, Francesca; Skoutari, Peter; Islam, Mohammad Shahidul; Saha, Samir K.; Walker, Ann Sarah; Whitelaw, Andrew; Sharland, Michael

doi:10.1016/j.eclinm.2024.102463

eClinicalMedicine

2024

DOI: 10.1016/j.eclinm.2024.102463

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Safety and efficacy of whole-body chlorhexidine gluconate cleansing with or without emollient in hospitalised neonates (NeoCHG): a multicentre, randomised, open-label, factorial pilot trial

Neal Russell,

Michelle N. Clements,

Kazi Shammin Azmery

et al.

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Cited by 2 publications

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Skin science to advance emollient therapy in the care and health of preterm infants

Darmstadt

2024

eClinicalMedicine

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Skin science to advance emollient therapy in the care and health of preterm infants

Darmstadt

2024

eClinicalMedicine

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Insights into the Cytotoxicity and Irritant Potential of Chlorhexidine Digluconate: An In Vitro and In Ovo Safety Screening

Dinu,

Matichescu,

Buzatu

et al. 2024

Dentistry Journal

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Chlorhexidine (CHX) represents one of the most commonly used antiseptics in dentistry and other medical–pharmaceutical fields due to its broad-spectrum antimicrobial activity. However, the potential toxic events arising from its common use in practice has become a subject of increasing concern. Thus, the present study was designed to investigate the potential toxicity of CHX digluconate at concentrations covering its antibacterial properties (0.0002–0.2%) in HGF primary gingival fibroblasts, HaCaT immortalized human keratinocytes, and JB6 Cl 41-5a epidermal cells, as well as its irritant action in ovo. Our results indicate that CHX exerted a concentration- and time-dependent cytotoxicity in all cell lines, which was evidenced by the reduction in cell viability, number, and confluence, damaged cell membrane integrity, impaired cell morphology, and specific apoptotic nuclear shape. The highest cytotoxicity was caused by CHX digluconate 0.02% and 0.2%, concentrations, at which an irritant effect on the chorioallantoic membrane was also observed. The novel findings revealed in this research contribute to the overall safety profile of CHX and stand as a basis for further investigations in this regard.

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Safety and efficacy of whole-body chlorhexidine gluconate cleansing with or without emollient in hospitalised neonates (NeoCHG): a multicentre, randomised, open-label, factorial pilot trial

Cited by 2 publications

References 38 publications

Skin science to advance emollient therapy in the care and health of preterm infants

Skin science to advance emollient therapy in the care and health of preterm infants

Insights into the Cytotoxicity and Irritant Potential of Chlorhexidine Digluconate: An In Vitro and In Ovo Safety Screening

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