Safety and efficacy of tacrolimus rescue therapy in 55 kidney transplant patients treated with cyclosporine

Urbizu, J.M.; Zárraga, Sofía; Gómez-Ullate, P; Amenábar, Juan José; Gaínza, FJ; Lampreabe, I; Virto, Jorge; Orbe, Josune

doi:10.1016/s0041-1345(03)00610-9

Cited by 9 publications

(2 citation statements)

References 10 publications

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“…There is less data on the newer immunosuppressive agents such as tacrolimus and mycophenylate mofetil. However, a reduction in serum uric acid upon changing from CsA to tacrolimus has been reported 7,8 and one case report notes that this has been helpful in the management of gout in a renal transplant recipient. 9 The mechanisms by which CsA contributes to hyperuricaemia and gout in the transplant population are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Gout in renal transplant recipients

Stamp

Searle

et al. 2006

Nephrology

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out is an important problem in the post-transplant population causing significant morbidity and time off work. Diuretics, impaired renal function, gout prior to transplantation and hyperuricaemia are important risk factors. The need for diuretic therapy should be kept under review in these patients. Hypouricaemic therapy should be considered early in those who develop gout post renal transplantation. Further studies are required to determine whether treatment for asymptomatic hyperuricaemia is justified.

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Section: Discussionmentioning

confidence: 99%

Gout in renal transplant recipients

Stamp

Searle

et al. 2006

Nephrology

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“…It is also worth considering to use alternative drugs or to alter the dosage pattern without compromising the primary effect for which the medication was prescribed. For example, switching from ciclosporin to tacrolimus (after transplantation) [282] or using the diuretic indapamide on alternate days for the treatment of hypertension [283]. Dietary measures can also help lower SUA levels [284].…”

Section: Concluding Commentsmentioning

confidence: 99%

Effect on Serum Uric Acid Levels of Drugs Prescribed for Indications other than Treating Hyperuricaemia

Daskalopoulou

Tzovaras²,

Mikhailidis³

et al. 2005

CPD

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Beyond allopurinol and the well-established uricosuric drugs, several other agents can decrease serum uric acid (SUA) levels, such as losartan, fenofibrate and some non-steroidal anti-inflammatory drugs (NSAIDs). Some of these drugs increase renal urate excretion. Hyperuricaemia and gout are common problems (at least 1% of Western men are affected by gout). Raised SUA levels increase the incidence of acute gout and renal calculi. Hyperuricaemia may also predict an increased risk of vascular events. Therefore, lowering SUA levels is of clinical relevance. In this review we consider the effect on SUA levels of drugs that are prescribed for indications other than treating hyperuricaemia. These drugs may obviate the need for specific treatment (e.g. allopurinol) aimed at lowering SUA levels. Furthermore, because hyperuricaemic patients may already be on several drugs (e.g. due to associated dyslipidaemia, hypertension and/or arthritis) compliance may be improved by avoiding additional medication. The potential for adverse effects associated with polypharmacy would also be decreased.

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