Safety and efficacy of selenium compounds (E8) as feed additives for all animal species: sodium selenite, based on a dossier submitted by Retorte GmbH Selenium Chemicals and Metals

,

doi:10.2903/j.efsa.2016.4398

Cited by 8 publications

(10 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous opinions, the FEEDAP Panel assessed the safety for the environment of the inorganic source of sodium selenite when used in animal nutrition up to the maximum authorised content in feed and concluded that not concerns to the environment were expected (EFSA FEEDAP Panel, 2015, 2016a. The additive under assessment, sodium selenate for use in complementary feed for ruminants in the form of ruminal boluses, is intended to be a substitute for other authorised selenium additives and will not further increase the environmental burden of selenium.…”

Section: Safety For the Environmentmentioning

confidence: 99%

Safety and efficacy of sodium selenate as feed additive for ruminants

Additives¹,

Bampidis²,

Azimonti³

et al. 2019

EFS2

View full text Add to dashboard Cite

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of sodium selenate as a nutritional feed additive for ruminants, when used via an intraruminal bolus in ruminants. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel concludes that based on (i) the estimation of the release of selenium from the bolus, (ii) the similarities in bioavailability with sodium selenite, (iii) the experience with the use of boluses in ruminant nutrition and (iv) the wide margin of safety compared with the maximum tolerable levels of selenium in ruminants, the additive is safe for ruminants. The use of sodium selenate by bolus administration providing a selenium intake not exceeding that resulting from the maximum authorised EU level of total selenium in feed presents no concerns for consumer safety. The additive does not pose a risk to users by inhalation and is considered as non-corrosive but irritant for the skin and the eyes. The FEEDAP Panel considers the additive as a skin sensitiser and respiratory sensitiser. The additive under assessment, in its intended use as complementary feed for ruminants in the form of boluses, is a substitute for other authorised selenium additives and will not further increase the environmental burden of selenium. Based on two studies submitted in cattle and sheep and studies from the literature, the FEEDAP Panel concludes that sodium selenate delivered by a bolus to ruminants is an efficacious source of selenium in meeting the animals' requirements. The Panel posed some recommendations regarding the use of the bolus, especially in small size ruminants. The Panel also posed a remark, concerning the zinc content of the bolus from which the additive is delivered.

show abstract

Section: Safety For the Environmentmentioning

confidence: 99%

Safety and efficacy of sodium selenate as feed additive for ruminants

Additives¹,

Bampidis²,

Azimonti³

et al. 2019

EFS2

View full text Add to dashboard Cite

show abstract

“…The toxicology of selenium, including organic forms, namely SeMet, has been extensively reviewed by the Scientific Committee on Food (SCF) (European Commission, 2000), the Agency for Toxic Substances and Disease Registry (ATSDR, 2003), the WHO (2011), the European Medicines Agency (EMA, 2015) and the FEEDAP Panel (EFSA, 2006(EFSA, , 2009EFSA FEEDAP Panel, 2011b,c, 2013a,b, 2014a,b, 2015, 2016a.…”

Section: Toxicological Studiesmentioning

confidence: 99%

Safety and efficacy of Zinc‐l‐Selenomethionine as feed additive for all animal species

Rychen¹,

Aquilina²,

Azimonti³

et al. 2018

EFS2

View full text Add to dashboard Cite

The additive, 'Zinc-L-selenomethionine' (Zn-L-SeMet) is intended to be used as a source of selenium for all animal species. The applicant intends to market the active compound blended with inert carriers (Availa ® Se). Zn-L-SeMet is a safe source of selenium for chickens for fattening; the conclusion is extended to all animal species. Selenium from Zn-L-SeMet does not elicit any adverse effects not expected for a selenium compound. The use of Zn-L-SeMet in animal nutrition is expected to result in a similar increase in selenium deposition in animal tissues/products as that resulting from other sources of SeMet. The use of the additive up to the maximum selenium supplementation level established for other sources of organic selenium (0.2 mg/kg complete feed) and complying with the maximum authorised total selenium content is safe for consumers. The additive is hazardous upon inhalation; owing to the high dusting potential, persons handling Availa ® Se are at risk by inhalation. Availa ® Se is not an irritant to the skin. In the absence of data, no conclusion on the eye irritation and skin sensitisation can be drawn. The use of Zn-L-SeMet in feed does not pose an additional risk to the environment, compared with other sources of selenium for which it will substitute, as long as the maximum authorised content in complete feed is not exceeded. Zn-L-SeMet is an effective source of selenium in chickens for fattening and laying hens; this conclusion is extended to all animal species. The maximum contribution of zinc in total feed deriving from the use of the additive (< 0.2 mg Zn/kg feed) is considered low and does not need any safety assessment except for users. Acknowledgements: The FEEDAP Panel wishes to thank the following for the support provided to this scientific output (in alphabetical order of the last name): Rosella Brozzi, Jaume Galobart and Paola Manini.

show abstract

“…The FEEDAP Panel has already adopted two opinions on sodium selenite in the frame of re-evaluation (EFSA FEEDAP Panel, 2015, 2016.…”

Section: Additional Informationmentioning

confidence: 99%

“…Symptoms of deficiency and toxicosis of selenium are described in detail in previous opinions of the FEEDAP Panel (EFSA, 2006;EFSA FEEDAP Panel, 2011b, 2016 and scientific reviews (e.g. McDowell, 2003;Suttle, 2010).…”

Section: Safety For the Target Speciesmentioning

confidence: 99%

“…The MTLs for horses and fish were derived from interspecies extrapolation and amount to 5 and 2 mg Se/kg DM feed, respectively. The NRC could not set MTLs for dogs and cats.The applicant provided a literature review on the effects of feed supplementation with sodium selenite for several animal species covering the years 2000 to present (database search CAB Abstracts).23 The most relevant studies found in this review for ruminants, poultry and pet animals were already summarised in an opinion recently delivered by the FEEDAP Panel on sodium selenite and are considered as valid(EFSA FEEDAP Panel, 2016). Other studies not mentioned so far do not add relevant new information.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Safety and efficacy of selenium compounds (E8) as feed additives for all animal species: Sodium selenite, based on a dossier submitted by Todini and Co SpA

Feed¹

2016

EFS2

View full text Add to dashboard Cite

Selenium is an essential trace element for vertebrates, involved in a series of vital metabolic functions. Sodium selenite is a safe and efficacious source of selenium for all animal species/categories. The use of sodium selenite as a source of selenium in animal nutrition is safe for the consumer, provided that the total maximum authorised content of selenium in complete feed is respected. The additive is an irritant to the skin, eyes and mucosae, whereas it is not a skin sensitiser. Systemic exposure to selenium could result from dermal contact. Users/workers handling the additive would be exposed to selenium by inhalation at levels which constitute a risk. The use of sodium selenite in animal nutrition up to the maximum authorised content in feed would not raise concerns to the environment.

show abstract

Safety and efficacy of selenium compounds (E8) as feed additives for all animal species: sodium selenite, based on a dossier submitted by Retorte GmbH Selenium Chemicals and Metals

Cited by 8 publications

References 58 publications

Safety and efficacy of sodium selenate as feed additive for ruminants

Safety and efficacy of sodium selenate as feed additive for ruminants

Safety and efficacy of Zinc‐l‐Selenomethionine as feed additive for all animal species

Safety and efficacy of selenium compounds (E8) as feed additives for all animal species: Sodium selenite, based on a dossier submitted by Todini and Co SpA

Contact Info

Product

Resources

About