Safety and Efficacy of Primary Multisession Dose Fractionated Gamma Knife Radiosurgery for Jugular Paragangliomas

Tripathi, Manjul; Rekhapalli, Rajashekhar; Batish, Aman; Kumar, Narendra; Oinam, Arun S; Ahuja, Chirag; Deora, Harsh; Aggarwal, Ashish; Mohindra, Sandeep; Kaur, Parwinder; Kaur, Rupinder; Bhatt, Sandeep; Gurnani, Jenil

doi:10.1016/j.wneu.2019.07.090

Cited by 18 publications

(11 citation statements)

References 25 publications

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“…A total of 29 studies have been identified 9‐37 . One study was a multicenter trial with 132 patients and was counted as a separate publication even though parts of the data had already been reported elsewhere.…”

Section: Resultsmentioning

confidence: 99%

Image‐guided robotic radiosurgery for glomus jugulare tumors—Multicenter experience and review of the literature

Ehret¹,

Kufeld²,

Fürweger

et al. 2020

Head & Neck

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Background: Glomus jugulare tumors (GJTs) are challenging to treat due to their vascularization and location. This analysis evaluates the effectiveness and safety of image-guided robotic radiosurgery (RRS) for GJTs in a multicenter study and reviews the existing radiosurgical literature. Methods: We analyzed outcome data from 101 patients to evaluate local control (LC), changes in pretreatment deficits, and toxicity. Moreover, radiosurgical studies for GJTs have been reviewed. Results: After a median follow-up of 35 months, the overall LC was 99%. Eighty-eight patients were treated with a single dose, 13 received up to 5 fractions. The median tumor volume was 5.6 cc; the median treatment dose for single-session treatments is 16 Gy, and for multisession treatments is 21 Gy. Fifty-six percentage of patients experienced symptom improvement or recovered entirely. Conclusions: RRS is an effective primary and secondary treatment option for GJTs. The available literature suggests that radiosurgery is a treatment option for most GJTs.

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Section: Resultsmentioning

confidence: 99%

Image‐guided robotic radiosurgery for glomus jugulare tumors—Multicenter experience and review of the literature

Ehret¹,

Kufeld²,

Fürweger

et al. 2020

Head & Neck

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“…Although a little lower, the symptom improvement rate after CKT in our study was not much deviated from that of past studies (48-56%). [2,4,14,8] Hearing impairment (33%) and tinnitus (47%) were likely to improve than other symptoms (Table 3) and this tendency was supported by a recent meta-analysis. [4] Univariate and multivariate analysis revealed that the status of no past surgical resection was a signi cant prognostic factor for better clinical outcome (Table 4).…”

Section: Symptom Improvement and Adverse Effectsmentioning

confidence: 73%

The Long-Term Outcome of Cyberknife Therapy for Head and Neck Paraganglioma: Management Suggestion From a Single Center Experience

Hong

Kagawa

Sato

et al. 2021

Preprint

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IntroductionTo analyze the long-term follow-up data of CyberKnife treatment (CKT) for head and neck paragangliomas (HNPGs). MethodsPatients who received CKT to HNPGs from 2010 to 2019 were retrospectively reviewed. ResultsA total of 34 HNPGs from 29 patients were identified. The mean age was 50 (± 16) years old, and 15 patients (52%) were female. Previous operation was done in 15 patients (55%). Four cases (14%) were functional in hormone production. According to Fisch classification, one case (3%) was B, 12 (42%) were C, 14 (48%) were D, and two cases (7%) were out of classification. The median prescribed dose covered 95% of the planning target volume was 2500 (IQR 2100 – 2600) cGy and the median target volume was 10 (IQR 5.8 – 21.3) cm3. The local control rate was 97%. The median progression-free survival was 66 (IQR 27.5 – 95.0) months and 93.8%, and 91.7% were free of tumor progression at five, and seven years respectively. During the follow-up, one case (3%) resulted in permanent facial nerve palsy (CTCAE 1, House-Brackmann grade II), and another case (3%) resulted in asymptomatic cerebellar radiation necrosis. Univariate and multivariate analysis showed no previous surgical history (OR 10.3, 95% CI 1.5 – 69.3, p = 0.02) was a positive predictor of symptom improvement. We devised a treatment flow-chart based on our finding. ConclusionsCKT for HNPGs was an effective treatment with little side effect over the long term and should be considered the first-line therapy for symptomatic nonfunctional HNPGs for better symptom control.

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“…Tripathi et al used a hypofractionated schedule using GK [36]. Gigliotti et al reported the results of Linac-based SRT [37].…”

Section: Paraganglioma (Glomus Tumor)mentioning

confidence: 99%

“…Gy (range, 15.0-16.0) to targets of 23.3 to 36.1 mm (mean 28.4) in diameter.Recent reported series are summarized inTable 5[4,[33][34][35][36][37].…”

mentioning

confidence: 99%

Stereotactic Radiosurgery and Stereotactic Radiotherapy for Malignant Skull Base Tumors

Mori¹,

Kida²,

Matsushita³

et al. 2020

Cureus

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The role of stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT) for malignant skull base tumors was summarized and discussed. The treatment of skull base tumors remains challenging. Their total resection is often difficult. SRS/SRT is one useful treatment option for residual or recurrent tumors after surgical resection in cases of primary skull base tumors. If skull base metastasis and skull base invasion are relatively localized, they can be candidates for SRS/SRT. Low rates of cervical lymph node involvement in early-stage (N0M0, no lymph node involvement or distant metastasis) nasal and paranasal carcinomas (NpNCa) and external auditory canal carcinomas (EACCa) have been reported in the literature. Such cases might be good candidates for SRS/SRT as the initial therapy. We previously reported the results of SRS/SRT for various malignant extra-axial skull base tumors. In addition, treatment results of early-stage head and neck carcinomas were summarized. Those of our data and those of other reported series were reviewed here to clarify the usefulness of SRS/SRT for malignant extraaxial skull base tumors.

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Safety and Efficacy of Primary Multisession Dose Fractionated Gamma Knife Radiosurgery for Jugular Paragangliomas

Cited by 18 publications

References 25 publications

Image‐guided robotic radiosurgery for glomus jugulare tumors—Multicenter experience and review of the literature

Image‐guided robotic radiosurgery for glomus jugulare tumors—Multicenter experience and review of the literature

The Long-Term Outcome of Cyberknife Therapy for Head and Neck Paraganglioma: Management Suggestion From a Single Center Experience

Stereotactic Radiosurgery and Stereotactic Radiotherapy for Malignant Skull Base Tumors

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