Safety and Efficacy of Polydioxanone Nano-Fibers as Anti-Inflammatory Agents

Abstract

PDOPDO nano-fibers were a kind gift of Dongbang Acupuncture Ltd, Korea. Phagocytosis assayPhagocytosis was assessed by flow cytometry using pHrodo AbstractThe use of biodegradable polydioxanone (PDO) nano-fibers for various purposes is increasing but the effects of these fibers on immune responses are not well understood. We examined the potential stimulatory and inhibitory effects of PDO coated fibers on immune cell functions in vitro in humans and in vivo in mice. Short term in vitro exposure of human blood to PDO did not perturb the phagocytic function of human monocytes and neutrophils. In contrast lymphocytes exhibited an increased proliferative function in response to polyclonal T cell mitogen, PHA. However, cytokine secretion by monocytes and lymphocytes as well as NK cell cytotoxic effector cell functions were undisturbed by PDO exposure. Long term in vivo exposure to PDO had no effect on dendritic cells activation, cytokine secretion and T regulatory induction. Injection of PDO into mice with rheumatoid arthritis suggested that PDO nano-fibers tend to be anti-inflammatory as an increase in IL-10 was observed in the PDO treated groups. In spite of this the arthritic score and TNF-α and IFN-γ levels were not significantly different between PDO-treated and untreated rheumatoid arthritis induced mice. In conclusion, PDO nano-fibers have no significant adverse effect on immune functions and tend to induce anti-inflammatory responses upon long term exposure in vivo.

Thread embedding acupuncture for musculoskeletal pain: a systematic review and meta-analysis protocol

“… 28 Another animal study mentioned that the injection of PDO into mice with rheumatoid arthritis had an anti-inflammatory effect by increasing interleukin-10. 29 …”

Shape-Memory Materials via Electrospinning: A Review

“…Another polymer that has been investigated is polydioxanone (PDX) since electrospun PDX presents similar mechanical properties to collagen and elastin [167] and has been widely used in drug/gene delivery. Moreover, PDX nanofibers have been studied as anti-inflammatory agents [168] in rotator cuff repair [169]. For instance, Kratz et al [170] designed a diblock PCL-b-PDX nanofibrous scaffold that revealed values of R f and R r in the range of 92-98%.…”

Safety of Aesthetic Medicine Procedures in Patients with Autoimmune Thyroid Disease: A Literature Review

“…The materials from which the lifting threads are made seem to be neutral in terms of triggering autoimmune reactions and some of them are even used in the treatment of autoimmune diseases by blocking autoimmune systemic response [81,82]. Autoimmune diseases, however, are a relative contraindication-the safety of the thread has not been established in these patients.…”