Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Sebaceous Gland Hyperplasia

Zelickson, Brian D.; Selim, Mona M.; Kilmer, Suzanne L.; Rohrer, Thomas E.; Newman, James; Jauregui, Lauren; Knape, William A.; Ebbers, Edward; Uecker, Darrin; Nuccitelli, Richard

doi:10.1097/dss.0000000000002154

Cited by 27 publications

(21 citation statements)

References 14 publications

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“…3B ). A nonsignificant risk clinical trial (approved by Biomedical Research Institute of America IRB) treating 222 of these lesions with 0.9–0.5 J resulted in clearance in 99% of the lesions within 60 days 14 ( Fig. 4 ).…”

Section: Resultsmentioning

confidence: 99%

Nano-Pulse Stimulation Therapy for the Treatment of Skin Lesions

Nuccitelli

2019

Bioelectricity

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Nano-Pulse Stimulation (NPS) therapy applies nanosecond pulsed electric fields to cells and tissues. It is a nonthermal modality that uses ultrashort pulses of electrical energy in the nanosecond domain. The cellular response to this therapy can be quite varied depending on the number of pulses applied and the total energy delivered. Reviewed in this study are some clinical trial data describing the effects of NPS therapy on normal skin as well as three different skin lesions as part of the first commercial application of this technology. NPS therapy has been found to clear seborrheic keratosis lesions with an 82% efficacy and sebaceous gland hyperplasia with a 99.5% efficacy. Pilot studies on warts indicated that 60% of the NPS-treated warts were completely cleared within 60 days. NPS therapy can be used to treat cellular lesions in the epidermis and dermis without affecting noncellular components such as collagen and fibrin.

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Section: Resultsmentioning

confidence: 99%

Nano-Pulse Stimulation Therapy for the Treatment of Skin Lesions

Nuccitelli

2019

Bioelectricity

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“…Pulse biosciences, a US based company has an ongoing active clinical study on its proprietary platform technology branded as Nano-Pulse Simulation TM . It makes use of electrically conducting microneedles to apply nano electric pulses at targeted tissue and is aimed to study the effect in benign skin tumors [ 182 , 183 ]. Nonetheless, this study is currently not recruiting or enrolling potential subjects [ 180 ].…”

Section: Clinical Trials (Cts) On Mns Of Anti-cancerous Drugsmentioning

confidence: 99%

Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update

et al. 2020

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Microneedles (MNs) are tiny needle like structures used in drug delivery through layers of the skin. They are non-invasive and are associated with significantly less or no pain at the site of administration to the skin. MNs are excellent in delivering both small and large molecules to the subjects in need thereof. There exist several strategies for drug delivery using MNs, wherein each strategy has its pros and cons. Research in this domain lead to product development and commercialization for clinical use. Additionally, several MN-based products are undergoing clinical trials to evaluate its safety, efficacy, and tolerability. The present review begins by providing bird’s-eye view about the general characteristics of MNs followed by providing recent updates in the treatment of cancer using MNs. Particularly, we provide an overview of various aspects namely: anti-cancerous MNs that work based on sensor technology, MNs for treatment of breast cancer, skin carcinoma, prostate cancer, and MNs fabricated by additive manufacturing or 3 dimensional printing for treatment of cancer. Further, the review also provides limitations, safety concerns, and latest updates about the clinical trials on MNs for the treatment of cancer. Furthermore, we also provide a regulatory overview from the “United States Food and Drug Administration” about MNs.

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“…Treatments with intense PEF are central for many existing and emerging medical applications, including tumor and tissue ablations [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Ablations by PEF rely primarily on breaking the plasma membrane barrier of the cells by electroporation, leading to irreversible changes in homeostasis and cell death.…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of Neurostimulation by Intense Nanosecond Pulsed Electric Fields: How to Avoid Firing in Peripheral Nerve Fibers

Kim

Gudvangen

Kondratiev³

et al. 2021

IJMS

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Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong involuntary muscle contractions and pain. Nanosecond-range PEF (nsPEF) are less efficient at neurostimulation and can be employed to minimize such side effects. We quantified the impact of the electrode configuration, PEF strength (up to 20 kV/cm), repetition rate (up to 3 MHz), bi- and triphasic pulse shapes, and pulse duration (down to 10 ns) on eliciting compound action potentials (CAPs) in nerve fibers. The excitation thresholds for single unipolar but not bipolar stimuli followed the classic strength–duration dependence. The addition of the opposite polarity phase for nsPEF increased the excitation threshold, with symmetrical bipolar nsPEF being the least efficient. Stimulation by nsPEF bursts decreased the excitation threshold as a power function above a critical duty cycle of 0.1%. The threshold reduction was much weaker for symmetrical bipolar nsPEF. Supramaximal stimulation by high-rate nsPEF bursts elicited only a single CAP as long as the burst duration did not exceed the nerve refractory period. Such brief bursts of bipolar nsPEF could be the best choice to minimize neuromuscular stimulation in ablation therapies.

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Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Sebaceous Gland Hyperplasia

Cited by 27 publications

References 14 publications

Nano-Pulse Stimulation Therapy for the Treatment of Skin Lesions

Nano-Pulse Stimulation Therapy for the Treatment of Skin Lesions

Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update

Peculiarities of Neurostimulation by Intense Nanosecond Pulsed Electric Fields: How to Avoid Firing in Peripheral Nerve Fibers

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