2005
DOI: 10.1111/j.1523-1755.2005.00395.x
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Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease

Abstract: In ADPKD patients, 6-month somatostatin therapy is safe and may slow renal volume expansion. This may reflect an inhibited growth in particular of smallest cysts beyond the detection threshold of CT scan evaluation. Whether this effect may prove renoprotective in the long term should be tested in additional trials of longer duration.

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Cited by 242 publications
(222 citation statements)
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“…Another clinical trial run in parallel with and independent of the study presented here found that a treatment period of the same duration (6 months) with another long-acting somatostatin analogue (lanreotide) achieved a reduction of liver volume in patients with autosomal-dominant polycystic liver disease or AD-PKD (15) similar to the reduction we observed in ADPKD patients. Finding that lanreotide also limited the growth of kidney volumes in the subgroup of patients with ADPKD confirmed and extended our previous data that the growth of ADPKD kidneys can be prevented by octreotide therapy (6).…”
Section: Discussionsupporting
confidence: 75%
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“…Another clinical trial run in parallel with and independent of the study presented here found that a treatment period of the same duration (6 months) with another long-acting somatostatin analogue (lanreotide) achieved a reduction of liver volume in patients with autosomal-dominant polycystic liver disease or AD-PKD (15) similar to the reduction we observed in ADPKD patients. Finding that lanreotide also limited the growth of kidney volumes in the subgroup of patients with ADPKD confirmed and extended our previous data that the growth of ADPKD kidneys can be prevented by octreotide therapy (6).…”
Section: Discussionsupporting
confidence: 75%
“…Main patient characteristics at inclusion have been reported in detail (6). Briefly, systolic and diastolic BP averaged 144 Ϯ 12 mmHg and 94 Ϯ 12 mmHg, respectively.…”
Section: Clinical Characteristicsmentioning
confidence: 99%
See 1 more Smart Citation
“…Four published trials examine the possible benefit of regular injection of a somatostatin analog, which aims at inhibition of cAMP production in renal cells and resultant cyst development and growth (39)(40)(41)(42). Essential data are summarized in Table 2.…”
Section: Somatostatin Analogsmentioning
confidence: 99%
“…Essential data are summarized in Table 2. Three small studies focused on polycystic liver disease and assessed effect on TKV as secondary end points; their data suggested marginal benefit on TKV (39)(40)(41). A fourth randomized controlled trial evaluated 70 ADPKD patients using octreotide over 3 years (42).…”
Section: Somatostatin Analogsmentioning
confidence: 99%