Safety and efficacy of l‐threonine produced by fermentation using Escherichia coli CGMCC 7.232 for all animal species

Additives, Efsa Panel on; Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Dusemund, Birgit; Kouba, Maryline; Durjava, Mojca Kos; López‐Alonso, Marta; Puente, Secundino López; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Cocconcelli, Pier Sandro; Costa, Lucio G.; Dierick, Noël; Flachowsky, Gerhard; Glandorf, Boet; Herman, Lieve; Kärenlampi, Sirpa; Mantovani, Alberto; Saarela, Maria; Anguita, Montserrat; Tarrés‐Call, Jordi; Wallace, Robert John

doi:10.2903/j.efsa.2018.5458

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…The Scientific Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) issued ten opinions on the safety and efficacy of L-threonine produced by genetically modified strains of E. coli (EFSA FEEDAP Panel, 2013, 2014a,b,c,d, 2015a,b, 2016a,b, 2017a, 2018a, 2019c or Corynebacterium glutamicum (EFSA FEEDAP Panel, 2019a,b).…”

Section: Additional Informationmentioning

confidence: 99%

Safety and efficacy of l‐threonine produced using Escherichia coliCGMCC 13325 as a feed additive for all animal species

Additives¹,

Bampidis²,

Azimonti³

et al. 2020

EFS2

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Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on l ‐threonine produced by fermentation when used as a nutritional additive in feed and water for drinking for all animal species and categories. The product under assessment is l ‐threonine produced using a genetically modified strain of E. coli CGMCC 13325. The Panel notes that three out of five batches of the additive do not comply with the minimum specification of 98.5% l ‐threonine on a dry matter basis proposed by the applicant. The production strain and its DNA were not detected in the final additive. Therefore, the final product does not give raise to any safety concern regarding the genetic modification of the production strain. The use of l ‐threonine produced using E. coli CGMCC 13325 in supplementing feed to compensate for threonine deficiency in feedingstuffs is safe for the target species. The FEEDAP Panel identified risks of nutritional imbalances and hygienic concerns for amino acids when administered simultaneously in feed and in water for drinking. The use of l ‐threonine produced by fermentation using E. coli CGMCC 13325 in animal nutrition is considered safe for the consumers and for the environment. There is a risk from the inhalation exposure to endotoxins for persons handling the additive. In the absence of data, the FEEDAP Panel cannot conclude on the potential of l ‐threonine produced using E. coli CGMCC 13325 to be a skin or eye irritant or a skin sensitiser. The additive under assessment is regarded as an effective source of the amino acid l ‐threonine for all non‐ruminant species. For the supplemental l ‐threonine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.

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Section: Additional Informationmentioning

confidence: 99%

Safety and efficacy of l‐threonine produced using Escherichia coliCGMCC 13325 as a feed additive for all animal species

Additives¹,

Bampidis²,

Azimonti³

et al. 2020

EFS2

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Additional Informationmentioning

confidence: 99%

“…The susceptibility of the strain was tested against the list of antibiotics proposed for Corynebacterium in the technical Guidance on the characterisation of microorganisms used as feed additives or as production organisms (EFSA FEEDAP Panel, ,b). ■■■■■■■■■■ C. glutamicum KCCM 80117 therefore fulfils all criteria for qualification as QPS.…”

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of l‐threonine produced by fermentation with Corynebacterium glutamicum KCCM 80117 for all animal species

Bampidis¹,

Azimonti²,

Bastos³

et al. 2019

EFS2

Self Cite

View full text Add to dashboard Cite

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐threonine produced by fermentation with Corynebacterium glutamicum ■■■■■ when used as a nutritional additive in feed and water for drinking for all animal species and categories. The product under assessment is l‐threonine produced by fermentation with a ■■■■■ strain of C. glutamicum (■■■■■). l‐Threonine produced by C. glutamicum ■■■■■ is considered safe for the target species when supplemented in appropriate amounts to the diet. The FEEDAP Panel has concerns on the safety of the simultaneous oral administration of l‐threonine via water for drinking and feed. l‐Threonine produced using C. glutamicum ■■■■■ is safe for the consumer. The additive is not a skin or eye irritant and is not a skin sensitiser. Although the workers can be exposed by inhalation, the results of an acute inhalation study showed that risk of adverse effects by inhalation is low. l‐Threonine produced using C. glutamicum ■■■■■ is safe for the environment. The product under assessment is considered an efficacious source of the amino acid l‐threonine for all animal species. For l‐threonine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.

show abstract

“…The Scientific Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) issued ten opinions on the safety and efficacy of l ‐threonine produced by genetically modified strains of E. coli (EFSA FEEDAP Panel, , ,b,c,d, ,b, ,b, , ).…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of l‐threonine produced by fermentation with Corynebacterium glutamicum ■■■■■ for all animal species

Bampidis¹,

Azimonti²,

Bastos³

et al. 2019

EFS2

Self Cite

View full text Add to dashboard Cite

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐threonine produced by fermentation with Corynebacterium glutamicum ■■■■■ when used as nutritional additive in feed and water for drinking for all animal species and categories. The product under assessment is l‐threonine produced by fermentation with a genetically modified strain of C. glutamicum (■■■■■). The production strain and its recombinant DNA were not detected in the additive. The product l‐threonine, manufactured by fermentation with C. glutamicum, ■■■■■ does not give rise to any safety concern with regard to the production strain. l‐Threonine produced using C. glutamicum ■■■■■ is considered safe for the target species. The FEEDAP Panel has concerns regarding the safety of the simultaneous oral administration of l‐threonine via water for drinking and feed. l‐Threonine produced using C. glutamicum ■■■■■ is safe for the consumer. The additive is not a skin or eye irritant and is not a skin sensitiser. Although the workers can be exposed by inhalation, the results of an acute inhalation study showed that risk of adverse effects by inhalation is low. l‐Threonine produced using C. glutamicum ■■■■■ is safe for the environment. The product under assessment is considered an efficacious source of the amino acid l‐threonine for all animal species. For l‐threonine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.

show abstract

Safety and efficacy of l‐threonine produced by fermentation using Escherichia coli CGMCC 7.232 for all animal species

Cited by 6 publications

References 16 publications

Safety and efficacy of l‐threonine produced using Escherichia coliCGMCC 13325 as a feed additive for all animal species

Safety and efficacy of l‐threonine produced using Escherichia coliCGMCC 13325 as a feed additive for all animal species

Safety and efficacy of l‐threonine produced by fermentation with Corynebacterium glutamicum KCCM 80117 for all animal species

Safety and efficacy of l‐threonine produced by fermentation with Corynebacterium glutamicum ■■■■■ for all animal species

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