Safety and efficacy of intranasal recombinant human interferon alfa 2b as prophylaxis for COVID-19 in patients on a hemodialysis program

Abstract

Introduction: Patients diagnosed with end-stage chronic kidney disease on a hemodialysis program (HDP) represent a risk group for COVID-19. Scientific societies have developed guidelines for the prevention of contagion, but there is no prophylactic medicine in them. Objectives: To describe the safety and efficacy of recombinant intranasal human Interferon alfa 2b as prophylaxis for COVID-19 in patients in an HDP. Patients and Methods: Intervention description through the monitoring of 15 patients in outpatient HDP. Prior to the administration of the drug, clinical, radiological evaluation and hematology and blood chemistry studies were performed. Daily contact was made with each study patient in person or by telephone, asking about the occurrence of adverse events or symptoms of disease. Results: In 47% of the patients, there was leukopenia, lymphopenia in 67% and anemia and thrombocytopenia in 33% respectively, prior to the use of the drug. There was no clinical suspicion of COVID-19 in any of them. Adverse events occurred in 3 patients (20%), all were mild and non-severe. All patients were negative for SARS-CoV-2 real-time polymerase chain reaction (rtPCR) and antibody studies 45 days after the study started. Conclusion: the use of intranasal recombinant human interferon alfa 2b as prophylaxis of COVID-19 in patients in a HDP at a dose of 1 MIU daily for ten days, as part of a prevention protocol, has an adequate safety profile. None of the patients in the series was infected with SARS-CoV-2 during the surveillance period.

COVID-19: Hematological and laboratory findings in patients from a private hospital in Caracas, Venezuela.Correlation with mortality

“…Wang demonstrated in a review of patients with COVID-19 the presence of 33 % of leukopenias (44). In other studies, leukopenia has been reported to be between 28.1 % and 68.1 %, depending on the severity of the disease and the underlying pathology, suggesting a possible association between severity of leukopenia and severity of COVID-19 (44)(45)(46)(47). Of the 41 patients with COVID-19 who died, the leukocyte count on admission was: 10.8 ± 6.2 × 10 9 / L, (of these 18 patients had leukocytosis with a white count ≥ 10 × 10 9 / L and only 2 patients had leukocytosis ≥20 × 10 9 / L).…”

Integration of human organoids single‐cell transcriptomic profiles and human genetics repurposes critical cell type‐specific drug targets for severe COVID‐19

“…Large proportions of these drugs have been experimented for the exhibited agonist-receptor interactions with IFNAR2, which could be used alone or in conjunction with other anti-virus drugs for against COVID-19 initiation and progression. 105,106 Several limitations of this study should be cautious. First, the power of the cell-type-level integration analysis is limited by the lack of scRNA-seq data and matched genetic information in each sample for discerning COVID-19-relevant cell types.…”

“…Large proportions of these drugs have been experimented for the treatment of severe COVID‐19. For example, the FDA‐approved drugs of INTERFERON ALFA‐2B and INTERFERON BETA‐1B exhibited agonist–receptor interactions with IFNAR2 , which could be used alone or in conjunction with other anti‐virus drugs for against COVID‐19 initiation and progression 105,106 …”

Integration of human organoids single-cell transcriptomic profiles and human genetics repurposes critical cell type-specific drug targets for severe COVID-19

“…Large proportions of these drugs have been experimented for the treatment of severe COVID-19. For example, the FDA-approved drugs of INTERFERON ALFA-2B and INTERFERON BETA-1B exhibited agonist-receptor interactions with IFNAR2, which could be used alone or in conjunction with other anti-virus drugs for against COVID-19 initiation and progression[89,90].…”