Safety and efficacy of intracameral injection of dexamethasone and moxifloxacin at the end of cataract surgery

Albialy, Hany Abdalhafiz; Wagih, Mostafa; Gouda, Doaa; Eid, Ashraf Mahrous

doi:10.21608/zumj.2019.19166.1616

Cited by 2 publications

(3 citation statements)

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“…These results are in agreement with Albialy et al, that demonstrated significant effect on cells and flare but no significant effect as far as IOP was concerned. 12 The same results were reported by Manzoor et al 13 However, it focused on anterior chamber reaction only. Contrary to our results, Gungor et al, showed no significant difference in anterior chamber cells and flare between use of intra-cameral dexamethasone and topical steroid formulation.…”

Section: Discussionsupporting

confidence: 64%

Effects of Intra-cameral Dexamethasone after Uncomplicated Phacoemulsification

Saad Jan,

Muhammad Ali Tahir,

Syed Muhammad Faisal

et al. 2023

pak J Ophthalmol

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Purpose: Postoperative inflammation is very common following phacoemulsification. We conducted this study to compare the effectiveness of intra-cameral dexamethasone injection with traditional topical steroids following phacoemulsification. Study Design: Quasi experimental Place and Duration of Study: Jinnah Postgraduate Medical Center, JPMC, Karachi from February 2022 to July 2022. Methods: A total of 60 patients were divided into two equal groups of 30 each. One group was treated with prophylactic intra-cameral dexamethasone at the end of phacoemulsification and the other group was given Balanced Salt Solution in its place. Both the groups were examined at post-operative day 1 and 7 for following parameters; best corrected visual acuity (BCVA), intra-ocular pressures (IOP), anterior chamber cells and flare. Results: The dexamethasone group showed statistically significant improvement in anterior chamber cells and flare as compared to the placebo group at postoperative day 1 and 7 (p-value of 0.042 and 0.029 respectively for cells; p-value of 0.038 and 0.002 respectively for flare). HoweverBCVA and IOP showed no statistically significant differences between the two groups at postoperative day 1 and 7 (p-value 0.67 and 0.46 respectively for BCVA and 0.22 and 0.08 respectively for IOP). Conclusion: Intra-cameral dexamethasone is an effective way to control postoperative inflammation following phacoemulsification with reduced anterior chamber cells and flare. However, its effects on BCVA and IOP were comparable to topical steroids.

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Section: Discussionsupporting

confidence: 64%

Effects of Intra-cameral Dexamethasone after Uncomplicated Phacoemulsification

Saad Jan,

Muhammad Ali Tahir,

Syed Muhammad Faisal

et al. 2023

pak J Ophthalmol

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“…One week postoperatively, only 3 eyes had +1 aqueous cells. All eyes of both groups had no detected anterior chamber cells at subsequent follow up visits 16 .…”

Section: Safety Of Prophylactic Intracameral Moxifloxacin Injection A...mentioning

confidence: 90%

“…More recently, Albialy et al (2019) showed that aqueous cells on the first postoperative day in the group of patients treated with injected intracamerally with moxifloxacin: five eyes had 2+, and 7 eyes had 1+ with no eyes of +3 or more.…”

Section: Safety Of Prophylactic Intracameral Moxifloxacin Injection A...mentioning

confidence: 99%

Safety of Prophylactic Intracameral Moxifloxacin Injection after Uncomplicated Phacoemulsification Surgery

Ashraf

Elkhouly

Nematalla

et al. 2022

Egyptian Journal of Ophthalmology, (Mansoura Ophthalmic Center)

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Purpose: Endophthalmitis is a serious inflammation that affect the eye and represents a major threat after cataract operation in the form of postoperative endophthalmitis (POE). With more than 10 million cataract operation performed yearly all over the world, effective POE prophylaxis is essential. Many postoperative prophylactic measures are available including Intracameral (IC), topical, subconjunctival and oral antibiotic preparations. Currently, although IC administration is widely accepted, there is no consensus on the best prophylactic therapy or route of administration for POE prevention.Objective: Determine the safety of prophylactic intracameral injection of moxifloxacin after uncomplicated phacoemulsification surgery. Patients and Methods:This prospective randomized study included 60 eyes of patients who had uncomplicated phacoemulsification cataract operation selected from Mansoura ophthalmic center, Mansoura University, Egypt, in the period from August 2017 to August 2018. After the surgery the cases were classified into two groups. The first group (30 eyes) received ordinary postoperative systemic and topical ocular treatment (Control group) and the second group (30 eyes) received ordinary postoperative systemic and topical ocular treatment in addition to injection with IC moxifloxacin at the end of operation. The cases were followed up at the following up at; first day,1 week, 1 month & 3 months after surgery Results: There was statistically significant difference in the BCVA, but there was no statistically significant difference in the central corneal thickness and endothelial cell count in the cases within the two groups 1 and 3 months of surgery. There was a statistically significant decrease in the central corneal thickness, endothelial cell count and number of cells in anterior chamber in the cases within the two groups along the follow up period after the surgery as compared with the preoperative value. Conclusion:The current study supported the safety of IC injection of undiluted moxifloxacin in a concentration of 0.5 mg /0.1 ml (vigamox) in terms of anterior chamber reaction, central corneal thickness, endothelial cell count and visual rehabilitation.

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Safety and efficacy of intracameral injection of dexamethasone and moxifloxacin at the end of cataract surgery

Cited by 2 publications

References 0 publications

Effects of Intra-cameral Dexamethasone after Uncomplicated Phacoemulsification

Effects of Intra-cameral Dexamethasone after Uncomplicated Phacoemulsification

Safety of Prophylactic Intracameral Moxifloxacin Injection after Uncomplicated Phacoemulsification Surgery

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