Safety and efficacy of intra-articular injection of platelet-rich plasma for the treatment of ankle osteoarthritis: a systematic review and meta-analysis

Ding, Shenglong; Ji, Linfeng; Zhang, Mingzhu; Xiong, Wei; Sun, Chengyi; Han, Zeyu; Wang, Chao

doi:10.1007/s00264-023-05773-2

Cited by 7 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MCID values from studies on other foot pathologies had to be considered. 6 , 8 , 12 , 16 Compared to these values, the results of the main outcome of this study can be considered clinically significant. The same conclusion can be drawn for the VAS pain results that surpassed the estimated MCID from a study on plantar heel pain by Landorf et al 21 (0.8-1.9).…”

Section: Discussionmentioning

confidence: 90%

“…Ten was considered an adequate difference because several studies have reported MCID values to be in the same range (7.9-30.2, 8.9, 8.9, and 9.5) in treatment of other foot pathologies. 6 , 10 , 12 , 16 The SD of 10 was estimated based on a similar study on treatment of plantar fasciitis with fasciotomy. 3 With a power of 80 and level of significance of 5%, 16 patients were needed in each group.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Outcomes After Proximal Medial Gastrocnemius Recession and Stretching vs Stretching as Treatment of Chronic Plantar Fasciitis at 6-Year Follow-up

Riiser,

Husebye,

Hellesnes

et al. 2023

Foot Ankle Int.

View full text Add to dashboard Cite

Background: Evidence from prospective short-term studies suggest that proximal medial gastrocnemius recession is a safe and efficient procedure to treat chronic plantar fasciitis resistant to nonoperative treatment. The aim of this study is to evaluate the long-term clinical outcomes of proximal medial gastrocnemius recession and stretching compared to a stretching exercise protocol for patients with chronic plantar fasciitis and an isolated gastrocnemius contracture (IGC). Methods: Forty patients with plantar fasciitis lasting more than 1 year were prospectively randomized to a home stretching exercise program only, or to proximal medial gastrocnemius recession in addition to the stretching program. Clinical and functional data in this study were obtained at baseline and 6-year follow-up. The main outcome was the American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score. Secondary outcomes were the visual analog scale (VAS) for pain, the Manchester Oxford Foot Questionnaire (MOxFQ), ankle dorsiflexion, and Achilles complex performance. Results: Thirty-three of 40 patients completed the 6-year follow-up. Seven patients had crossed over from nonoperative treatment to operative treatment. At 6 years, the operative group demonstrated significantly better outcomes with AOFAS (88.9 vs 78.6, P = .012), for pain measured by VAS (2.5 vs 5.5, P < .001) and with the MOxFQ total score (24.4 vs 45.9, P = .05) (per protocol analysis excluding crossovers). No between-group differences were observed for ankle dorsiflexion or Achilles complex performance at 6 years. Conclusion: This study demonstrates that the improved function and reduced level of pain by proximal medial gastrocnemius recession and stretching is better compared to stretching alone after 6 years of follow-up for patients with chronic plantar fasciitis and a concomitant isolated gastrocnemius contracture. Level of Evidence: Level I, randomized controlled trial.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Outcomes After Proximal Medial Gastrocnemius Recession and Stretching vs Stretching as Treatment of Chronic Plantar Fasciitis at 6-Year Follow-up

Riiser,

Husebye,

Hellesnes

et al. 2023

Foot Ankle Int.

View full text Add to dashboard Cite

show abstract

“…Due to its alleged ability to expedite the healing process, APG has gained widespread usage in the wound repair field. 11 , 12 Being the second generation of platelet-derived preparations, APG offers several added benefits, including readily available materials, ease of product, affordability, and no risk of rejection reaction. An increasing amount of research indicates that APG is superior to standard care or conventional treatment for chronic wound management.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Autologous Platelet-Rich Plasma Gel for Diabetic Foot Ulcer Care Among Older Adults: A Systematic Review and Meta-Analysis

Platini,

Adammayanti,

Maulana

et al. 2024

TCRM

View full text Add to dashboard Cite

Introduction Poorly controlled diabetes mellitus can lead to the development of diabetic foot ulcers (DFU), which is a frequent complication in patients. However, several diabetes management guidelines for older adults do not mention the occurrence of DFUs. Nowadays, Autologous Platelet-Rich Gel (APG) is being used for treating diabetic ulcers. APG is an innovative platelet-derived product with many advantages, such as being low-cost, easy to produce, and readily available materials. Additionally, it does not lead to any rejection reaction. Objective This study aims to assess the safety and efficacy of APG as a novel treatment of DFU compared with standard treatment in older adult patients. Methods Randomized Controlled Trials (RCTs) were searched using PubMed, Cochrane, Google Scholar, Wiley, and PlosOne. The keywords have been arranged using the Boolean operator, including autologous platelet-rich gel, DFU, and elderly. The data was screened by inclusion and exclusion criteria. The final inclusion study was analyzed and synthesized by tabulation, clusterization, contextual and thematic approach, and assessed for risk of bias using ROB 2.0. Meta-analysis was conducted by using Review Manager 5.4 and the Mantel Haenszel method. Results Eight RCTs with 598 patients were eligible for the present analysis. Compared with standard care/conventional treatment, APG could significantly improve the healing wound in patients with diabetic foot ulcers (Relative risk (RR) 1.32, 95% confidence interval (CI) 1.22–1.57, p < 0.0001), shortened the healing time (Mean difference [MD] −16.97 days (95% CI: −32.64 to −1.29; p < 0.00001), shortened the length of hospital stay (MD= −20.11, 95% CI: −38.02, −2.20; p = 0.03), and amputation rate (MD= 0.36, 95% CI: 0.16, 0.84; p = 0.02). Conclusion APG treatment can better treat DFU in terms of duration of healing, wound healing, length of hospital stay, and amputation prevention than the standard treatment.

show abstract

“…The most common cause of ankle OA is previous trauma, unlike knee OA, which occurs as a result of the primary OA. Thus, ankle OA patients are usually younger than knee OA patients (Boffa et al, 2021; Ding et al, 2023; Laohajaroensombat et al, 2023). Treatments that are considered for OA of the knee, depending on the severity of the deterioration, include pharmacological treatment, physiotherapy, bracing, prolotherapy, and surgical operation (Hsiao et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The efficacy of curcumin in relieving osteoarthritis: A meta‐analysis of meta‐analyses

Bideshki,

Jourabchi‐Ghadim,

Radkhah

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases. Several meta‐analyses have shown that curcumin could improve the function of the knee and alleviate pain in OA, while some meta‐analyses demonstrate controversial results. Hence, we assessed curcumin's effects on knee OA in an umbrella meta‐analysis. PubMed, Scopus, Embase, and Web of Science databases were employed to find English‐language meta‐analyses of randomized controlled trials investigating the effect of curcumin supplementation on OA outcomes up to September 2023. The visual analog scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain, function, and stiffness scales were analyzed. Effect sizes and 95% confidence intervals were utilized to obtain the overall effect size. A random‐effects model was applied to perform the meta‐analysis. Heterogeneity was determined by I2 statistics and the Cochrane Q‐test. The pooled effect of the 11 included meta‐analyses showed that curcumin could significantly decrease the VAS score (weighted mean difference [WMD] and standardized mean difference [SMD]), WOMAC‐total (SMD and WMD), WOMAC‐Function (SMD and WMD), WOMAC‐Pain (SMD), and WOMAC‐Stiffness scores (SMD) (p ≤ 0.001, ≤0.001, ≤0.001, 0.007, ≤0.001, 0.002, ≤0.001, ≤0.001, respectively). The results strongly support curcuminoid supplementation in relieving pain, improving joint mobility and stiffness, and shortening medication usage of OA patients.

show abstract

Safety and efficacy of intra-articular injection of platelet-rich plasma for the treatment of ankle osteoarthritis: a systematic review and meta-analysis

Cited by 7 publications

References 52 publications

Outcomes After Proximal Medial Gastrocnemius Recession and Stretching vs Stretching as Treatment of Chronic Plantar Fasciitis at 6-Year Follow-up

Outcomes After Proximal Medial Gastrocnemius Recession and Stretching vs Stretching as Treatment of Chronic Plantar Fasciitis at 6-Year Follow-up

The Potential of Autologous Platelet-Rich Plasma Gel for Diabetic Foot Ulcer Care Among Older Adults: A Systematic Review and Meta-Analysis

The efficacy of curcumin in relieving osteoarthritis: A meta‐analysis of meta‐analyses

Contact Info

Product

Resources

About