Safety and Efficacy of Intra-articular Injection of Platelet-Rich Plasma in Patients With Ankle Osteoarthritis

Abstract

Level IV, case series.

The use of stromal vascular fraction (SVF), platelet-rich plasma (PRP) and stem cells in the treatment of osteoarthritis: an overview of clinical trials

“…However, this finding has not been approved at later months [59]. Just one study has pointed to the efficacy of PRP in patients with ankle OA, which again has shown that PRP can significantly reduce pain in these patients [60] (Figure 1).…”

Autologous platelet‐rich gel treatment for diabetic chronic cutaneous ulcers: A meta‐analysis of randomized controlled trials

“…Autologous platelet‐rich gel is an inexpensive and immunologically safe source of growth factors. It is believed that APG can accelerate the healing process, so APG has been widely used in the field of wound repair . As a second‐generation platelet‐derived preparation, APG has some additional advantages, such as consisting of easy‐to‐obtain materials, being simple to produce, low cost, and no rejection reaction.…”

“…It is believed that APG can accelerate the healing process, so APG has been widely used in the field of wound repair. 12,13 As a second-generation platelet-derived preparation, APG has some additional advantages, such as consisting of easy-to-obtain materials, being simple to produce, low cost, and no rejection reaction. A growing body of evidence suggests that APG is more effective for chronic wounds than standard care or conventional treatment.…”

Effect and mechanism of total alkaloids of strychnine on papain induced rabbit knee osteoarthritis

“…However, there are also problems such as short duration of curative effect, increased cost, and inappropriate use of patients in advanced stage and increased risk of infection in multiple articular cavities [8][9][10][11]. In recent years, the new therapies, such as the articular cavity injection of Platelet rich plasma (PRP) and mesenchymal stem cells (MSCs) appear which can improve the clinical symptoms of especially patients with the early osteoarthritis such as significantly reducing joint pain, promoting the articular cartilage repair and delay the degeneration of articular cartilage [12][13][14]. Few adverse reactions were reported [12,15].…”