2019
DOI: 10.1016/s1473-3099(19)30310-x
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Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial

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Cited by 28 publications
(30 citation statements)
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“…In contrast to the single-dose injection required for LZV, this gamma-irradiated vaccine utilizes a four-dose regimen [21]. However, although the new vaccine is not efficacious in patients with hematological malignancies, it is effective for the prevention of HZ in chemotherapy patients with solid tumor malignancies [19]. Thus, though not currently available, this new vaccine is expected to be used in immune-compromised adults and post-transplant recipients.…”
Section: Hz Vaccine Historymentioning
confidence: 99%
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“…In contrast to the single-dose injection required for LZV, this gamma-irradiated vaccine utilizes a four-dose regimen [21]. However, although the new vaccine is not efficacious in patients with hematological malignancies, it is effective for the prevention of HZ in chemotherapy patients with solid tumor malignancies [19]. Thus, though not currently available, this new vaccine is expected to be used in immune-compromised adults and post-transplant recipients.…”
Section: Hz Vaccine Historymentioning
confidence: 99%
“…Currently, a new inactivated vaccine made from Zostavax ® by gamma irradiation was introduced and has been tested. Phase II/III trials have shown that this new inactivated version of LZV is well tolerated, has favorable effects in patients with malignancies, and does not possess significant safety issues [ 19 - 21 ]. In contrast to the single-dose injection required for LZV, this gamma-irradiated vaccine utilizes a four-dose regimen [ 21 ].…”
Section: Main Bodymentioning
confidence: 99%
“…The reported incidence of HZ in auto-HSCT recipients, despite antiviral prophylaxis, ranges from 62 of 1000 person-years (PYs), based on a large retrospective analysis [ 4 ], to 92 of 1000 PYs, based on a recent phase 3 randomized clinical trial [ 7 ]. For patients with solid tumor malignancies receiving chemotherapy (STMc), reports of HZ incidence range from 15 of 1000 PYs [ 3 ] to 19 of 1000 PYs [ 8 ]. For patients with hematologic malignancies (HMs), HZ incidence is reported to be 31 of 1000 PYs [ 2 , 6 , 8 ].…”
mentioning
confidence: 99%
“…For patients with solid tumor malignancies receiving chemotherapy (STMc), reports of HZ incidence range from 15 of 1000 PYs [ 3 ] to 19 of 1000 PYs [ 8 ]. For patients with hematologic malignancies (HMs), HZ incidence is reported to be 31 of 1000 PYs [ 2 , 6 , 8 ]. In comparison, HZ incidence in the the general adult population is 5 of 1000 PYs [ 9 ].…”
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confidence: 99%
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