Safety and Efficacy of Hypofractionated Stereotactic Radiosurgery in Facial Nerve Schwannoma

Abstract

ObjectiveIn the current era of modern neurosurgery, the treatment strategies have been shifted to “nerve-preservation approaches” for achieving a higher facial and hearing function preservation rate following facial nerve tumors. We have conducted this novel report on determining the outcome of patients with facial nerve schwannomas (FNS) treated with hypofractionated stereotactic radiosurgery (hfSRS).PatientsRetrospective chart review of a prospectively maintained database search was conducted.InterventionPatients who underwent hfSRS CyberKnife (Accuray Inc, Sunnyvale, CA, U.S.A.) for FNS were included.Main Outcome MeasuresOutcomes consisted of tumor control, facial and hearing nerve function as graded by House-Brackmann and American Academy of Otolaryngology-Head and Neck Surgery recommendations, and adverse radiation effects.ResultsWith an institutional board review approval, we retrospectively identified five patients with FNS (four intracranial [80%] and one extracranial [20%]) treated with hfSRS (2011–2019). Patients received definitive SRS in three patients (60.0%), whereas adjuvant to surgical resection in two patients (40.0%). A median tumor volume of 7.5 cm3 (range, 1.5–19.6 cm3) received a median prescription dose of 23.2 Gy (range, 21–25 Gy) administered in median of three fractions (range, three to five sessions). With a median radiographic follow-up of 31.4 months (range, 13.0–71.0 mo) and clinical follow-up of 32.6 months (range, 15.1–72.0 mo), the local tumor control was 100.0%. At the last clinical follow-up, the facial nerve function improved or remained unchanged House-Brackmann I–II in 80.0% of the patients, whereas the hearing nerve function improved or remained stable in 100.0% of the patients. Temporary clinical toxicity was observed in three patients (60.0%), which resolved. None of the patients developed adverse radiation effect.ConclusionFrom our case series, hfSRS in FNS seems to be safe and efficacious in terms of local tumor control, and improved facial and hearing nerve function.

Facial nerve schwannoma and other benign neoplastic facial nerve lesions

“…A previous study reported that the treatment-induced exacerbation of facial nerve paralysis significantly increased with surgery, whereas there was no significant difference in local control rates between surgery and radiotherapy for intracranial facial nerve schwannomas [15]. Regarding local tumor control rate, preservation of facial nerves, and hearing ability, hypofractionated stereotactic radiosurgery is reported to be more beneficial in radiosurgery [16 ▪▪ ].…”