Safety and Efficacy of High-Dose Tranexamic Acid in Spine Surgery: A Retrospective Single-Institution Series

Brown, Nolan J.; Pennington, Zach; Himstead, Alexander; Yang, Chenyi; Chakravarti, Sachiv; Gendreau, Julian; Kurtz, Joshua; Shahrestani, Shane; Pham, Martin H.; Osorio, Joseph A.

doi:10.1016/j.wneu.2023.04.058

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…Additionally, as blood loss can be significant in certain complex spine procedures, the use of hemostatic agents such as transexamic acid and other antifibrinolytic agents has become more common. These agents have the potential to become embolic and may be associated with an increased risk of vascular occlusion if they enter the systemic circulation, although no study has demonstrated a difference in thrombotic rate with tranexamic acid (TXA) [72][73][74].…”

Section: Central Retinal Artery Occlusionmentioning

confidence: 99%

Perioperative Blindness in Spine Surgery: A Scoping Literature Review

Sperber,

Owolo,

Zachem

et al. 2024

JCM

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Perioperative vision loss (POVL) is a devastating surgical complication that impacts both the recovery from surgery and quality of life, most commonly occurring after spine surgery. With rates of spine surgery dramatically increasing, the prevalence of POVL will increase proportionately. This scoping review aims to aggregate the literature pertinent to POVL in spine surgery and consolidate recommendations and preventative measures to reduce the risk of POVL. There are several causes of POVL, and the main contribution following spine surgery is ischemic optic neuropathy (ION). Vision loss often manifests immediately following surgery and is irreversible and severe. Diffusion weighted imaging has recently surfaced as a diagnostic tool to identify ION. There are no effective treatments; therefore, risk stratification for counseling and prevention are vital. Patients undergoing prone surgery of long duration and/or with significant expected blood loss are at greatest risk. Future research is necessary to develop effective treatments.

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Section: Central Retinal Artery Occlusionmentioning

confidence: 99%