Safety and Efficacy of Extremely Low LDL-Cholesterol Levels and Its Prospects in Hyperlipidemia Management

Bandyopadhyay, Dhrubajyoti; Qureshi, Arshna; Ghosh, Sayantani; Kumar, Ashish; Heise, Lyndsey R.; Hajra, Adrija; Ghosh, Raktim

doi:10.1155/2018/8598054

Cited by 41 publications

(31 citation statements)

References 36 publications

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“…Recent data confirm safety of very low levels of LDL-c down to 15 mg/dl. Combination therapy should be initiated after reaching the highest tolerable doses of statin [25,26].…”

Section: Resultsmentioning

confidence: 99%

Untitled

2019

JPNB

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“…Recent data confirm safety of very low levels of LDL-c down to 15 mg/dl. Combination therapy should be initiated after reaching the highest tolerable doses of statin [25,26].…”

Section: Resultsmentioning

confidence: 99%

Untitled

2019

JPNB

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“…Leptin particulates in cholesterol-regulating functions via proprotein convertase subtilisin/kexin type 9 pathway and down-regulates expression of LDL receptors in hepatocytes, leading to elevated plasma LDL-C levels and dyslipidemia [ 35 ]. High levels of HDL-C can lower your risk for cardiovascular diseases, while high LDL-C levels have opposite effects [ 36 , 37 ]. Among our postmenopausal participants, we observed the findings that circulating adiponectin levels are significantly positively associated with HDL-C levels ( Table 2 ) and leptin levels are highly correlated with LDL-C ( Table 3 ), consistent with previous reports [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Relationships between depression and anxiety symptoms and adipocyte-derived proteins in postmenopausal women

Huang²,

Kor

et al. 2021

PLoS ONE

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Introduction Studies on the association between adiponectin and leptin and anxiety and depression among postmenopausal women are limited. Therefore, the present study specifically evaluates the mutual relationships between adiponectin and leptin and anxiety and depression in postmenopausal women. Participants and design In this cross-sectional study, a total of 190 women aged 40–65 years were enrolled. Depression symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D), and anxiety symptoms were evaluated using the Hamilton Anxiety Rating Scale (HAM-A). Fasting specimens were collected to measure sex hormone, glucose, insulin, and adipokine levels. Multiple linear regression analysis was performed to evaluate the associations between depression and anxiety and adipocyte-derived hormones. Settings The study was performed in a hospital medical center. Results Among 190 enrolled postmenopausal women, Spearman’s rank correlation analysis revealed significant correlations between CES-D and HAM-A (r = 0.715, P < 0.0001), between CES-D and adiponectin (p = 0.009) and leptin (p = 0.015), and between HAM-A and adiponectin (p = 0.01) and leptin (p = 0.001). The subjects with CES-D ≥ 16 and with HAM-A ≥ 18 had higher adiponectin levels than those with CES-D < 16 and HAM-A < 18, respectively. After adjusting for age, body mass index, exercise, alanine amino transferase and parameters of lipid profiles, Log adiponectin levels were found to be significantly associated with both CES-D and HAM-A, and Log leptin levels were only significantly associated with HAM-A. Conclusions The data show that adiponectin and leptin levels are significantly associated with depression and anxiety symptoms. These results suggest that higher adiponectin and lower leptin levels may serve as potential markers related to anxiety and mood in postmenopausal women. More future research that is designed to deal with the important confounders (e.g., population heterogeneity) is needed to investigate comprehensively on these associations.

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“…40 There were previous reports regarding the reduction LDL-c, TC and TG levels related decreased risk in cardiovascular complications. 41,42 A metaanalysis demonstrated that the reduction in LDL-C of lowrisk subjects with HMG-CoA reductase inhibitors and this LDL-C reduction associated cardiovascular mortality. 43 Our systematic review showed that triphala treatment significantly decreased FBS and HbA1c in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

Phimarn

Sungthong

Itabe

2021

J Evid Based Complementary Altern Med

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Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

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Safety and Efficacy of Extremely Low LDL-Cholesterol Levels and Its Prospects in Hyperlipidemia Management

Cited by 41 publications

References 36 publications

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Relationships between depression and anxiety symptoms and adipocyte-derived proteins in postmenopausal women

Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

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