Safety and efficacy of chromium methionine (Availa® Cr) as feed additive for all species

,

doi:10.2903/j.efsa.2009.1043

Cited by 5 publications

(1 citation statement)

References 178 publications

(144 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The legality of adding supplemental chromium to animal diets varies among countries and animal species [10]. Chromium is not authorized as a feed additive in the European Union to avoid additional exposure of consumers resulting from the use of supplemental chromium in animal nutrition [11]. In the United States, Food and Drug Administration (FDA) permission or approval is required for any chromium source to be supplemented to animal diets [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary chromium picolinate supplementation on broiler growth performance: A meta-analysis

et al. 2021

View full text Add to dashboard Cite

Objective A meta-analysis was conducted to assess the effects of dietary chromium picolinate (CrPic) supplementation on broiler growth performance and to determine whether such effects are regulated by broiler strains, sex, environmental stress, or contextual factors including study area and years. Methods Eligible studies were identified by searching the Web of Science, Springer, Elsevier, ScienceDirect, Taylor & Francis Online databases. Weighted average differences with corresponding 95% confidence intervals were computed with a random-effects model. We performed subgroup analysis stratified by study area, published years, broiler strains and sex, and environmental stress. Publication bias was assessed with Egger’s test method. A total of 15 studies eligible for inclusion. Results The results indicated that CrPic supplementation significantly improved broiler growth performance and subgroup analysis confirmed this conclusion. We also found that Ross 308 or male broilers might be more sensitive to CrPic supplementation and showed better growth performance. A model was used to obtain the amount of chromium addition under the optimal growth performance, which suggested that the maximum value of average daily gain (ADG) was reached when chromium addition was 1810 μg/kg. The results of the sensitivity analysis showed low sensitivity and high stability of the meta-analysis. Conclusions CrPic supplementation had a positive effect on the growth performance of broilers, and this meta-analysis provides a more accurate value of chromium addition, which may be beneficial for the practice of the broiler industry.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of dietary chromium picolinate supplementation on broiler growth performance: A meta-analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

Dietary Supplementation with Chromium Picolinate Influences Serum Glucose and Immune Response of Brown-Egg Laying Hens

Zhang

Sun

Liao

et al. 2018

Biol Trace Elem Res

View full text Add to dashboard Cite

To investigate the effect of chromium picolinate (CrPic) on egg production performance, egg quality, blood indices, and immune function of laying hens, 270 23-week-old Beijing Red brown-egg laying hens were randomly assigned to one of three treatments with six replicates of 15 birds per replicate for each treatment in a completely randomized design. Laying hens were fed a Cr-unsupplemented corn-soybean meal basal diet (control, containing 0.45 mg Cr/kg by analysis) or the basal diet supplemented with 0.4 or 0.6 mg Cr/kg from CrPic for 10 weeks. Laying hens fed diets supplemented with CrPic had a lower (P < 0.05) serum glucose (GLU) concentration and higher (P < 0.03) serum antibody titer against Newcastle disease than those fed the control diet at 33 weeks of age. However, supplemental CrPic had no effect (P > 0.05) on egg production and egg quality of brown-egg laying hens from 24 to 33 weeks of age. The results from this study indicated that supplemental CrPic decreased serum GLU and enhanced the immune function of brown-egg laying hens.

show abstract

Safety and efficacy of Availa®Cr (chromium chelate of DL‐methionine) as a feed additive for dairy cows

Additives¹,

Bampidis²,

Azimonti³

et al. 2020

EFS2

View full text Add to dashboard Cite

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Availa®Cr (active compound: chromium chelate of DL‐methionine) as a feed additive for dairy cows. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel was assigned to this mandate. The tolerance study did not show adverse effects with respect to body weight, milk yield, haematology and blood biochemistry up to the 10‐fold overdose of chromium from Availa®Cr; however, owing to deficiencies in design and reporting of the study, it provided only supportive evidence on the safety of the additive. A safe level for dairy cows could be derived from a toxicological study with laboratory rodents. Taking all together, the FEEDAP Panel considers the maximum recommended use level (8 mg Cr from Availa®Cr/cow per day; about 0.4 mg Cr/kg complete feed) as safe. Chromium DL‐Met shows a genotoxic activity in vitro that is not expressed in vivo after systemic exposure; although no data on genotoxicity at the site of contact are available, the Panel notes that chromium(III) is not carcinogenic and concludes that chromium DL‐Met is unlikely to pose a carcinogenic risk at levels occurring in the diet. The use of Availa®Cr in feed of dairy cows up to the recommended supplementation level would not measurably increase consumer exposure to chromium(III), and therefore is safe for consumers. The additive poses a risk to users by inhalation, it is not an irritant to skin and eyes and should be considered a sensitiser. The use of the additive is not expected to pose a risk to the environment. Since only one study could be considered for the efficacy assessment, and three studies are required, the FEEDAP Panel cannot conclude on the efficacy of Availa®Cr for dairy cows.

show abstract

Safety and efficacy of chromium methionine (Availa® Cr) as feed additive for all species

Cited by 5 publications

References 178 publications

Effects of dietary chromium picolinate supplementation on broiler growth performance: A meta-analysis

Effects of dietary chromium picolinate supplementation on broiler growth performance: A meta-analysis

Dietary Supplementation with Chromium Picolinate Influences Serum Glucose and Immune Response of Brown-Egg Laying Hens

Safety and efficacy of Availa®Cr (chromium chelate of DL‐methionine) as a feed additive for dairy cows

Contact Info

Product

Resources

About