Safety and efficacy of biologics in childhood systemic lupus erythematosus: a critical systematic review

Elshaer, Rawan; Jaber, Samar; Odeh, Nour; Arbili, Lana; Al-Mayouf, Sulaiman M.

doi:10.1007/s10067-023-06833-z

Clin Rheumatol

2023

DOI: 10.1007/s10067-023-06833-z

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Safety and efficacy of biologics in childhood systemic lupus erythematosus: a critical systematic review

Rawan Elshaer,

Samar Jaber,

Nour Odeh

et al.

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2024

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Cited by 2 publications

References 48 publications

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Updates in the care and management of children and adolescents with systemic lupus erythematosus

Silva,

Aikawa,

Bonfa

2024

Current Opinion in Rheumatology

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Purpose of review This narrative review offers an update of the most important recent articles published in the previous year of childhood-onset systemic lupus erythematosus (cSLE), focusing on care and management. Recent findings Age-related disparities may play a significant role in the clinical and laboratory characteristics of cSLE, as well as its performance in distinct classification criteria. Monogenic lupus is associated with higher disease damage scores and mortality rate compared to sporadic cSLE. Adolescent face unique challenges, with comorbid psychiatric diagnosis, low resilience and nonadherence posing relevant challenges. A recent international task force has outlined pivotal principles and points-to-consider for treat-to-target (T2T) in cSLE patients. While the past year did yield new randomized controlled trial for cSLE treatment, publications focused on broader management strategies, including the impact of ultraviolet radiation exposure, immunization, and strict blood pressure control. Additionally, case reports and series have evaluated the efficacy/safety profiles of both available and emerging treatments. Summary Current studies highlighted the various facets of cSLE, epidemiology, clinical, laboratory, classification criteria, adolescent issues, prognosis, surveillance, T2T approach and drug management. Despite notable progress, the scarcity of randomized trials emphasizes the need to delineate safer and more efficacious treatment modalities in cSLE.

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Updates in the care and management of children and adolescents with systemic lupus erythematosus

Silva,

Aikawa,

Bonfa

2024

Current Opinion in Rheumatology

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Renal disease in pediatric rheumatology

Cody,

Brunner

2024

Current Opinion in Rheumatology

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Purpose of review This review will provide updates in the outcomes in the common rheumatologic diseases with kidney involvement. Covered are also advances in therapeutics for the use of pediatric rheumatologic diseases with kidney involvement, as well as the potential kidney complications from other rheumatologic diseases and their medications. Recent findings Two of the more common rheumatologic diseases with kidney involvement, lupus and vasculitis, continue to show inadequate response to initial therapy of renal disease and practice continues to be driven by results of adult studies. Summary There is a continued need for pediatric specific studies in rheumatologic diseases with kidney involvement as outcomes continue to be inadequate. Despite recently approved treatments for adults with rheumatic diseases and kidney involvement, therapeutic options in pediatrics remain limited, contributing to the overall morbidity and mortality.

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Safety and efficacy of biologics in childhood systemic lupus erythematosus: a critical systematic review

Cited by 2 publications

References 48 publications

Updates in the care and management of children and adolescents with systemic lupus erythematosus

Updates in the care and management of children and adolescents with systemic lupus erythematosus

Renal disease in pediatric rheumatology

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