Safety and Efficacy of an Artificial Tear Containing 0.3% Hyaluronic Acid in the Management of Moderate-to-Severe Dry Eye Disease

Rosa, Alberto López-de la; Pinto-Fraga, José; Arauzo, Francisco Blázquez; Rodríguez, Rubén Urbano; González-García, María J.

doi:10.1097/icl.0000000000000284

Cited by 25 publications

(33 citation statements)

References 33 publications

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“…While earlier studies have measured and compared tear meniscus height using the Schirmer test and anterior segment swept-source optical coherence tomography, 12,13 the measurement of this parameter with the Keratograph exhibits high reliability and repeatability. 14 In our study, we observed a significant increase in tear meniscus height at 1 week and 1 month. Traditionally, conjunctival hyperemia is assessed using visual scales, 15 which are subjective, while the analysis of conjunctival hyperemia using the Keratograph, is a quick and easy process.…”

Section: Discussionsupporting

confidence: 56%

<p>Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use</p>

Molina-Solana

Domínguez-Serrano

Garrido-Hermosilla

et al. 2020

OPTH

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Purpose: Artificial tears only provide transient relief for dry eye. To the best of our knowledge, this is the first study to objectively compare treatment with artificial tears with Keratograph 5M, which allows accurate and objective investigation of dry eye and artificial tear treatment. We aimed to evaluate whether a preservative-free combination of 0.4% hyaluronic acid and 0.2% galactoxyloglucan can improve dry eye using the new topographer, Keratograph 5M. Patients and Methods: This prospective longitudinal, single-arm interventional cohort study was performed at a tertiary referral center and involved 20 patients with dry eye (40 eyes). Preservative-free artificial tears were administered every 3 h. The participants underwent clinical and instrumental evaluations at baseline, 15, 30, 60, 90 and 120 min after instillation and 1 week and 1 month after treatment. Baseline values were considered as the controls. All patients were assessed with Keratograph 5M for non-invasive Keratograph first break-up time and non-invasive Keratograph average break-up time, conjunctival hyperemia, and tear meniscus height. Ocular surface staining with fluorescein was evaluated using the slit-lamp and fluorescein break-up time examinations, and the Ocular Surface Disease Index score was recorded for each patient. Results: The signs and symptoms improved after 1 month of preservative-free 0.4% hyaluronic acid and 0.2% galactoxyloglucan treatment. There was a significant increase in the non-invasive Keratograph first break-up time and non-invasive Keratograph average break-up time at 15, 30, 60, and 90 min, and 1 week and 1 month (P < 0.05) and a decrease in hyperemia, corneal staining, and Ocular Surface Disease Index scores after 1 week and 1 month (P < 0.05). No treatment-related adverse event was observed. Conclusion: A combination of 0.4% hyaluronic acid and 0.2% galactoxyloglucan artificial tears seems effective for treating dry eye. Keratograph 5M can objectively detect these changes during the follow-up period.

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Section: Discussionsupporting

confidence: 56%

<p>Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use</p>

Molina-Solana

Domínguez-Serrano

Garrido-Hermosilla

et al. 2020

OPTH

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“…These results coincided with previous researchers [31][32][33] who confirmed that, SH acts as a tissue lubricant through its high viscosity that modulates the interactions between neighboring tissues and provides mechanical protection of corneal epithelium and endothelium. Moreover, lubricating topical SH eye drops promoted water retention on corneal surface, accelerated corneal wettability and extended the time of drug contact with cornea so; it enhanced drug bioavailability and protected ocular surface epithelium by facilitating corneal epithelial healing [34] .…”

Section: Discussionsupporting

confidence: 92%

The protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits: A histological and immunohistochemical study

Mousa

El-Mahalaway

El-Desoky

2018

Egyptian Journal of Histology

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Introduction: Chlorinated-water-induced corneal wounds lead to reduced transparency and disability of the cornea. Sodium hyaluronate (SH) is a natural lubricant with unique hygroscopic properties that control tissue hydration for topical eye care with excellent use as an ophthalmic product. Aim of the work:To evaluate the protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits. Materials and Methods: A total of 20 adult male rabbits were divided equally into four groups treated with 2 drops of sodium hyaluronate on the corneal surface of both eyes two times daily for one month as follow: Group I (G1) was control group treated with distilled water, group II (G2) treated with chlorinated water, group III (G3) treated with SH while, group IV (G4) was treated with 2 drops of SH then 2 drops of chlorinated water. The corneas were excised and processed for histological and immunohistochemical study. Results: G2 showed epithelial thinning with some areas of cellular ulceration. Disturbance of normal stromal architecture, wide separation of collagen fibers and few degenerated keratocytes were noticed. In addition, a significant decrease of BCL-2 immunoexpression was observed in the cytoplasm of corneal epithelial cells (P<0.01). G3 and G4 showed improvement in the histological and immunohistochemical changes described in G2. Conclusion: Chlorinated water was harmful to the cornea and SH eye drops proved to minimize these corneal complications. Therefore, application of SH eye drops before swimming is recommended to flush chlorine drops away and to allow the tear film to remain over the cornea.

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“…Gel eye drops do not allow accurate and reproducible drug administration and can cause blurred vision, crusting on the eyelids, and tearing [9][10][11]. In general, these formulations consist of cellulose derivatives, such as carboxymethylcellulose (CMC) [12,13], hydroxypropylmethylcellulose (HPMC) [14,15], carbomer (carbopol), or hyaluronic acid (HA) [16][17][18]. Cellulose derivatives were the first polymeric materials to be applied as excipients in ophthalmic pharmaceutical forms [19].…”

Section: Gel Eye Dropsmentioning

confidence: 99%

Gel-Based Materials for Ophthalmic Drug Delivery

Cassano

Gioia

Trombino

2021

Gels

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The most common route of administration of ophthalmic drugs is the topical route because it is convenient, non-invasive, and accessible to all patients. Unfortunately, drugs administered topically are not able to reach effective concentrations. Moreover, their bioavailability must be improved to decrease the frequency of administrations and their side effects, and to increase their therapeutic efficiency. For this purpose, in recent decades, particular attention has been given to the possibility of developing prolonged-release forms that are able to increase the precorneal residence time and decrease the loss of the drug due to tearing. Among these forms, gel-based materials have been studied as an ideal delivery system because they are an extremely versatile class with numerous prospective applications in ophthalmology. These materials are used in gel eye drops, in situ gelling formulations, intravitreal injections, and therapeutic contact lenses. This review is intended to describe gel-based materials and their main applications in ophthalmology.

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Safety and Efficacy of an Artificial Tear Containing 0.3% Hyaluronic Acid in the Management of Moderate-to-Severe Dry Eye Disease

Abstract: Visaid 0.3% is a safe product with some benefits over 0.9% NaCl in reducing ocular symptoms and improving some ocular signs in patients with moderate-to-severe dry eye.

Cited by 25 publications

References 33 publications

<p>Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use</p>

<p>Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use</p>

The protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits: A histological and immunohistochemical study

Gel-Based Materials for Ophthalmic Drug Delivery

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